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p53 codon 72 polymorphism and the risk of lung cancer in a Korean population
- Source :
- Lung cancer (Amsterdam, Netherlands). 73(3)
- Publication Year :
- 2010
-
Abstract
- The aim of this study was to assess whether p53 codon 72 polymorphism is associated with an increased risk of lung cancer (LC) in a South Korean population. We conducted a population-based, large-scale, case-control study including 3939 patients with LC and 1700 controls. P53 codon 72 polymorphism was determined by real-time polymerase chain reaction (PCR). The frequencies of p53 codon 72 polymorphisms ( Arg / Arg , Arg / Pro , and Pro / Pro ) in LC were 37.0%, 46.2%, and 16.7%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively ( p Arg / Pro and Pro / Pro genotype were significantly associated with increased risk of LC (odds ratio (OR)=1.22, 95% confidence interval (CI)=1.06–1.14 and OR=1.83, 95% CI=1.48–2.26, respectively) compared with the Arg / Arg genotype. Risk was compared in different subgroups. The OR of Pro / Pro genotype was significantly higher in small cell lung cancer (SCC) and squamous cell carcinoma (SQC) than in adenocarcinoma (ADC). Higher OR of Pro / Pro genotype was also seen among males. However, relationships between gender, age, smoking, and genotypes were not found. P53 codon 72 polymorphism was associated with an increased risk of LC in this Korean population; the association was especially noteworthy in SQC, SCC, and males.
- Subjects :
- Pulmonary and Respiratory Medicine
Adult
Male
Risk
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Gastroenterology
law.invention
Gene Frequency
law
Internal medicine
Genotype
medicine
Humans
Lung cancer
Codon
Allele frequency
Polymerase chain reaction
Genetic Association Studies
Aged
Genetics
Korea
Polymorphism, Genetic
business.industry
Carcinoma
Odds ratio
Middle Aged
medicine.disease
Confidence interval
Oncology
Codon 72 polymorphism
Adenocarcinoma
Female
Tumor Suppressor Protein p53
business
Subjects
Details
- ISSN :
- 18728332
- Volume :
- 73
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Lung cancer (Amsterdam, Netherlands)
- Accession number :
- edsair.doi.dedup.....101d6d2a123f6a4bb9ad24bde166a9b8