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Coexistence of thyroid autoimmunity with other autoimmune diseases: Friend or foe? Additional aspects on the mosaic of autoimmunity
- Source :
- Autoimmunity. 38:247-255
- Publication Year :
- 2005
- Publisher :
- Informa UK Limited, 2005.
-
Abstract
- Autoimmunity encompasses a wide spectrum of diseases from organ-specific diseases like Hashimoto thyroiditis, to systemic diseases such as systemic lupus erythematosus. These diseases are characterized by inflammation and the production of a wide range of autoantibodies directed against multiple autoantigens. Although their etiology is still poorly understood, genetic, immunological, hormonal, and environmental factors are major predisposing and triggering factors. These multiple factors, like pieces in a mosaic, may interplay in different forms, leading to the expression of various autoimmune manifestations and diseases. This phenomenon, which has been referred by us as the "mosaic of autoimmunity", illuminates the diversity of autoimmune manifestations among susceptible individuals. From this theoretical framework we conducted a wide search of the literature, on the prevalence of thyroid autoimmunity, the commonest of the autoimmune conditions, among other autoimmune diseases, and discuss the possible clinical significance of this association.
- Subjects :
- Autoimmune disease
biology
business.industry
Immunology
Thyroiditis, Autoimmune
Autoantibody
Autoimmunity
medicine.disease_cause
medicine.disease
Thyroiditis
Autoimmune Diseases
Thyroid peroxidase
Immunopathology
Prevalence
medicine
biology.protein
Etiology
Humans
Immunology and Allergy
Clinical significance
business
Autoantibodies
Subjects
Details
- ISSN :
- 1607842X and 08916934
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Autoimmunity
- Accession number :
- edsair.doi.dedup.....103765af8078f80aa07541ed55f24480
- Full Text :
- https://doi.org/10.1080/08916930500050194