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Astaxanthin reduces isoflurane-induced neuroapoptosis via the PI3K/Akt pathway
- Source :
- Molecular Medicine Reports. 13:4073-4078
- Publication Year :
- 2016
- Publisher :
- Spandidos Publications, 2016.
-
Abstract
- Astaxanthin is an oxygen-containing derivative of carotenoids that effectively suppresses reactive oxygen and has nutritional and medicinal value. The mechanisms underlying the effects of astaxanthin on isoflurane‑induced neuroapoptosis remain to be fully understood. The present study was conducted to evaluate the protective effect of astaxanthin to reduce isoflurane‑induced neuroapoptosis and to investigate the underlying mechanisms. The results demonstrated that isoflurane induced brain damage, increased caspase‑3 activity and suppressed the phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (Akt) signaling pathway in an in vivo model. However, treatment with astaxanthin significantly inhibited brain damage, suppressed caspase‑3 activity and upregulated the PI3K/Akt pathway in the isoflurane‑induced rats. Furthermore, isoflurane suppressed cell growth, induced cell apoptosis, enhanced caspase‑3 activity and downregulated the PI3K/Akt pathway in organotypic hippocampal slice culture. Administration of astaxanthin significantly promoted cell growth, reduced cell apoptosis and caspase‑3 activity, and upregulated the PI3K/Akt pathway and isoflurane‑induced neuroapoptosis. The present study demonstrated that downregulation of the PI3K/Akt pathway reduced the effect of astaxanthin to protect against isoflurane‑induced neuroapoptosis in the in vitro model. The results of the current study suggested that the protective effect of astaxanthin reduces the isoflurane-induced neuroapoptosis via activation of the PI3K/Akt signaling pathway.
- Subjects :
- Male
0301 basic medicine
Cancer Research
Apoptosis
Xanthophylls
Biology
Biochemistry
Rats, Sprague-Dawley
Phosphatidylinositol 3-Kinases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Downregulation and upregulation
Astaxanthin
Genetics
Animals
Molecular Biology
Protein kinase B
PI3K/AKT/mTOR pathway
Isoflurane
Cell growth
Akt/PKB signaling pathway
Rats
Cell biology
030104 developmental biology
Oncology
chemistry
Brain Injuries
Molecular Medicine
Signal transduction
Proto-Oncogene Proteins c-akt
030217 neurology & neurosurgery
Signal Transduction
Subjects
Details
- ISSN :
- 17913004 and 17912997
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Molecular Medicine Reports
- Accession number :
- edsair.doi.dedup.....105c12cea9c54b5dac9591e0bbdc4453