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Infliximab as the First Retreatment in Patients with Kawasaki Disease Resistant to Initial Intravenous Immunoglobulin
- Source :
- The Pediatric infectious disease journal. 35(4)
- Publication Year :
- 2015
-
Abstract
- Forty-three patients with Kawasaki disease who were resistant to initial intravenous immunoglobulin (IVIG) were randomized to receive either a second dose of IVIG (n = 32) or an infliximab (n = 11). With IVIG retreatment 21 patients (65.6%) responded, and with infliximab 10 patients (90.9%) responded. The infliximab group had shorter duration of fever and fewer days of hospitalization. Coronary artery outcomes and adverse events were similar.
- Subjects :
- musculoskeletal diseases
Microbiology (medical)
Male
medicine.medical_specialty
Adolescent
Treatment outcome
Drug Resistance
Drug resistance
030204 cardiovascular system & hematology
Mucocutaneous Lymph Node Syndrome
Gastroenterology
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Internal medicine
medicine
Humans
In patient
030212 general & internal medicine
skin and connective tissue diseases
Adverse effect
Child
biology
business.industry
Immunoglobulins, Intravenous
Infant
medicine.disease
Coronary Vessels
Infliximab
Surgery
Infectious Diseases
Treatment Outcome
Child, Preschool
Pediatrics, Perinatology and Child Health
Retreatment
biology.protein
Kawasaki disease
Female
Antibody
business
medicine.drug
Subjects
Details
- ISSN :
- 15320987
- Volume :
- 35
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Pediatric infectious disease journal
- Accession number :
- edsair.doi.dedup.....105eb4d30d2554ca64c68996feb9acc9