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Anti-FGFR3 antibody epitopes are functional sites and correlate with the neuropathy pattern
- Source :
- Journal of Neuroimmunology. 361:577757
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Antibodies against FGFR3 define a subgroup of sensory neuropathy (SN). The aim of this study was to identify the epitope(s) of anti-FGFR3 autoantibodies and potential epitope-dependent clinical subtypes. Using SPOT methodology, five specific candidate epitopes, three in the juxtamembrane domain (JMD) and two in the tyrosine kinase domain (TKD), were screened with 68 anti-FGFR3-positive patients and 35 healthy controls. The identified epitopes cover 6/15 functionally relevant sites of the protein. Four patients reacted with the JMD and 11 with the TKD, partly even in a phosphorylation-state dependent manner. The epitope could not be identified in the others. Patients with antibodies recognizing TKD exhibited a more severe clinical and electrophysiological impairment than others.
- Subjects :
- Adult
Male
Sensory Receptor Cells
Immunology
Nerve Tissue Proteins
Autoantigens
Epitope
Epitopes
Autoimmune Diseases of the Nervous System
Protein Domains
Ganglia, Spinal
medicine
Humans
Receptor, Fibroblast Growth Factor, Type 3
Immunology and Allergy
Phosphorylation
Autoantibodies
biology
Autoantibody
Middle Aged
medicine.disease
Peripheral neuropathy
Epitope mapping
Neurology
Sensation Disorders
Sensory neuropathy
biology.protein
Female
Neurology (clinical)
Antibody
Protein Processing, Post-Translational
Tyrosine kinase
Subjects
Details
- ISSN :
- 01655728
- Volume :
- 361
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology
- Accession number :
- edsair.doi.dedup.....106e27b62f88f0b2360604fd90773c39
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2021.577757