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Anti-FGFR3 antibody epitopes are functional sites and correlate with the neuropathy pattern

Authors :
Lauriane Mohr
Yannick Tholance
Karine Ferraud
Jean-Philippe Camdessanché
Christian P. Moritz
Evelyne Reynaud-Federspiel
Jean-Christophe Antoine
Martin Jung
Source :
Journal of Neuroimmunology. 361:577757
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

Antibodies against FGFR3 define a subgroup of sensory neuropathy (SN). The aim of this study was to identify the epitope(s) of anti-FGFR3 autoantibodies and potential epitope-dependent clinical subtypes. Using SPOT methodology, five specific candidate epitopes, three in the juxtamembrane domain (JMD) and two in the tyrosine kinase domain (TKD), were screened with 68 anti-FGFR3-positive patients and 35 healthy controls. The identified epitopes cover 6/15 functionally relevant sites of the protein. Four patients reacted with the JMD and 11 with the TKD, partly even in a phosphorylation-state dependent manner. The epitope could not be identified in the others. Patients with antibodies recognizing TKD exhibited a more severe clinical and electrophysiological impairment than others.

Details

ISSN :
01655728
Volume :
361
Database :
OpenAIRE
Journal :
Journal of Neuroimmunology
Accession number :
edsair.doi.dedup.....106e27b62f88f0b2360604fd90773c39
Full Text :
https://doi.org/10.1016/j.jneuroim.2021.577757