Does non-operative management of iatrogenic bile duct injury result in impaired quality of life? A systematic review

Background Several studies have reported the effect of bile duct injury (BDI) on health-related quality of life (HRQOL) with conflicting results. This systematic review aims to study the impact of patient and treatment factors on HRQOL after BDI. Methods A search of the PubMed database was performed and studies were reviewed as per the PRISMA guidelines. Selected studies (n = 11) were then divided into two subgroups depending on whether they found HRQOL to be similar or worse between BDI and control groups. Pooled rates of surgical repair and major BDI were calculated for each of these subgroups. Results Surgical repair rates were 99% (95% CI: 96%–99%) in studies where the BDI patients had similar outcomes to controls, compared to 78% (40%–100%) where their outcomes were significantly worse (p = 0.091). The major BDI rate was 51% (95% CI: 42%–61%) in studies where the BDI patients had similar outcomes to controls, compared to 72% (41%–94%) where their outcomes were significantly worse (p = 0.322). Considerable heterogeneity was present within the two subgroups (I2: 68–99%). Discussion HRQOL may be adversely affected amongst patients with BDI who do not undergo surgical repair. Significant heterogeneity of data suggests the need for standardised HRQOL tools and injury severity systems when assessing outcomes after BDI.