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Noninvasive models to predict liver fibrosis in patients with chronic hepatitis B: a study from Turkey

Authors :
Ergenekon Karagoz
Esma Yuksel
Gunay Tuncer Ertem
Cahide Sacligil
Kaya Suer
Füsun Zeynep Akçam
Hayrettin Akdeniz
İhsan Çelik
Selcan Arslan Ozel
Unal Cagir
Murat Sayan
Pinar Korkmaz
Derya Keten
Alper Şener
Zerrin Yulugkural
Sinan Ozturk
Aysel Kocagul Celikbas
Eyup Arslan
Nese Saltoglu
Yeşim Alpay
Zehra Beştepe Dursun
Fatma Sirmatel
Hüseyin Şener Barut
Selmin Dirgen Çaylak
Bilgehan Aygen
Neşe Demirtürk
Muhammed Bekçibaşı
Arzu Tigli
Kemal Avsar
Asim Ulcay
Elif Sargin Altunok
Faruk Karakeçili
Gulfem Akengin Ocal
Sua Sumer
Gule Aydin
Ayse Batirel
Burcu Bayrak
O. Ural
Alpaslan Tanoglu
Sıla Akhan
Ahmet Cem Yardimci
H. Tarakci
Fatma Yılmaz Karadağ
Rezan Harman
Aynur Aynioglu
Neslihan Demir
Ayten Kadanali
Salih Atakan Nemli
Fatime Korkmaz
Necla Tulek
MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
Dirgen Çaylak, Selmin
Selçuk Üniversitesi
Zonguldak Bülent Ecevit Üniversitesi
BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
Sırmatel, Fatma
Akdeniz, Hayrettin
Tıp Fakültesi
Source :
Journal of Hepatology. 66:S679-S680
Publication Year :
2017
Publisher :
Elsevier BV, 2017.

Abstract

Alpay, Yeşim (Balikesir Author)<br />"Background: Manynoninvasive methods, including aspartateaminotransaminase (AST)/alanineaminotransaminase (ALT) ratio (AAR), AST-to-platelet ratio index (APRI), Bonacini cirrhosis discriminant score (CDS), fibrosis-4 (FIB4) index, and age-platelet index (API), have been described to determine the stage of hepatic fibrosis. However, thesemethodsare developed for patients with chronic hepatitisC(CHC) andproduce conflicting results in the prediction of liver fibrosis in patients with chronic hepatitis B (CHB). Objectives: The aim of this study was to evaluate the relationship between 7 noninvasive models, including AAR, APRI, CDS, API, FIB-4, neutrophil-to-lymphocyte ratio (NLR), and red cell distribution width (RDW)-to-platelet ratio (RPR) in patients with CHB. Methods: The study population included all patients with CHB, undergoing liver biopsy to determine HBsAg and HBV DNA positivity in more than 6 months. Results: A total of 2520 treatment-naive CHB patients from 40 different centers were included in the study. In total, 62.6% of the patients were male, and the mean age was 40.60 +/- 12.34 years (minimum, 18 years; maximum, 77 years). The Ishak fibrosis score was >= 3 in 29.8% of the patients, indicating significant fibrosis. The mean API, APRI, CDS, NLR, FIB4, and RPR scores in the noninvasive models were significantly different between the groups with significant and low fibrosis (P < 0.05). All the noninvave models (API, APRI, AAR, CDS, NLR, RPR, and FIB4) were found to be significant in the discrimination of cirrhosis (P < 0.05). In the multiple logistic regression analysis, CDS, albumin, alkaline phosphatase (ALP), total bilirubin, neutrophil count, NLR, mean platelet volume (MPV), and FIB4 were independent indices for cirrhosis. Conclusions: In the present study, the role of noninvasive tests in the prediction of liver fibrosis stage and cirrhosis was evaluated in a large cohort of CHB patients. Overall, noninvasive models are gradually becoming more promising. Accordingly, the need for liver biopsy can be reduced with a combination of noninvasive methods in the future."

Details

ISSN :
01688278
Volume :
66
Database :
OpenAIRE
Journal :
Journal of Hepatology
Accession number :
edsair.doi.dedup.....107efd4bd6d5bcf4b912dd3665b504e2
Full Text :
https://doi.org/10.1016/s0168-8278(17)31830-5