Increased miR-21-3p and miR-487b-3p serum levels during anaphylactic reaction in food allergic children

Background Anaphylaxis is the most severe manifestation of allergic disorders. The poor knowledge of its molecular mechanisms often leads to under‐diagnosis. MicroRNAs (miRNA) regulate physiologic and pathologic processes, and they have been postulated as promising diagnostic markers. The main objectives of this study were to characterize the human miRNA profile during anaphylaxis and to assess their capacity as diagnostic markers and determine their participation in the molecular mechanisms of this event. Methods The miRNA serum profiles from the acute and baseline phase of 5 oral food‐challenged anaphylactic children (