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Investigation of the impact of antinuclear antibody on the outcome of in vitro fertilization/intracytoplasmic sperm injection treatment
- Source :
- Taiwanese Journal of Obstetrics & Gynecology, Vol 54, Iss 6, Pp 742-748 (2015)
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Objective The aim of this study is to investigate the influence of antinuclear antibodies (ANAs) on the pregnancy and early miscarriage rates, thereby evaluating the outcome of in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI) treatment. Materials and methods A total of 517 infertile female patients undergoing IVF/ICSI treatment (experimental group) were chosen for this study, and 186 women with normal reproductive history (control group) were designated as the control. Serum ANAs from the participants were tested using indirect immunofluorescence assay, while antiextractable nuclear antigens were tested by immune blot assay. Results The ANA expression in the infertile patients (39.45%) was higher than that in the control group (16.13%). A high ANA titer (≥1:320) was found only in infertile patients. ANA positivity significantly decreased the pregnancy rate and increased the early miscarriage rate after IVF/ICSI treatment. The rate of early miscarriage was higher in the high-ANA-titer individuals after IVF/ICSI treatment. Clinical pregnancy rate in anti-scl-70- and anti-PM-scl-positive individuals after IVF/ICSI treatment was lower than that in the ANA-negative individuals. Anti-Rib-p, anti-Jo-1, and anti-dsDNA were found to cause high risk of early miscarriage in pregnant women. Conclusion ANA positivity may not only be the cause of bad outcome during IVF/ICSI treatment, but also pose as a risk factor for IVF/ICSI treatment.
- Subjects :
- Infertility
Adult
Ribosomal Proteins
medicine.medical_specialty
China
Anti-nuclear antibody
Pregnancy Rate
medicine.medical_treatment
Oocyte Retrieval
antinuclear antibodies
Fertilization in Vitro
lcsh:Gynecology and obstetrics
Intracytoplasmic sperm injection
Miscarriage
immune blot assay
Pregnancy
Obstetrics and Gynaecology
medicine
Humans
Sperm Injections, Intracytoplasmic
skin and connective tissue diseases
lcsh:RG1-991
reproductive and urinary physiology
Gynecology
In vitro fertilisation
Obstetrics
business.industry
urogenital system
Female infertility
in vitro fertilization/intracytoplasmic sperm injection
Obstetrics and Gynecology
medicine.disease
Abortion, Spontaneous
Pregnancy rate
indirect immunofluorescence assay
Antibodies, Antinuclear
Case-Control Studies
embryonic structures
Female
business
infertility
therapeutics
Infertility, Female
Subjects
Details
- ISSN :
- 10284559
- Volume :
- 54
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Taiwanese Journal of Obstetrics and Gynecology
- Accession number :
- edsair.doi.dedup.....10908eb84e1682cb1c49acd505dd168f
- Full Text :
- https://doi.org/10.1016/j.tjog.2015.09.001