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Urethral substitution using autologous lingual mucosal grafts: an experimental study
- Source :
- BJU international. 101(6)
- Publication Year :
- 2007
-
Abstract
- OBJECTIVE To investigate the feasibility of urethral substitution using free lingual mucosa grafts (LMGs) in a dog model. MATERIALS AND METHODS The study included 10 female mongrel dogs in which a 4 × 1 cm2 section of urethral mucosa was excised. The defect was immediately repaired with a size-matched free LMG harvested from the inferior lateral surface of the tongue. A 12 F urethral catheter was kept inside the urethra for a mean of 7 days. At 3 months after the procedure, the patency of the urethra was assessed by both insertion of a 12 F catheter and by retrograde urethrography. Dogs were killed, the grafted areas excised, and evaluated by gross and histopathological examination. RESULTS All dogs survived the procedure and there were no tongue complications. One of the 10 dogs developed a slight urethral stricture near the proximal anastomosis. The remaining nine dogs voided spontaneously with no difficulty. Retrograde urethrography showed that no strictures or fistulas had formed. The LMGs shortened by 9.5% after surgery, from a mean (sd) of 4 (0.13) to 3.62 (0.11) cm (statistically significant, P
- Subjects :
- medicine.medical_specialty
Urethral stricture
Urology
Urethral stenosis
Transplantation, Autologous
Dogs
Urethra
Tongue
medicine
Urethral mucosa
Animals
Urethral Stricture
Mongrel dogs
Lingual Frenum
business.industry
Lingual mucosa
medicine.disease
Surgery
Catheter
medicine.anatomical_structure
Treatment Outcome
Feasibility Studies
Urologic Surgical Procedures
Female
business
Subjects
Details
- ISSN :
- 1464410X
- Volume :
- 101
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- BJU international
- Accession number :
- edsair.doi.dedup.....10a8cd5a1fffc75045e30adf8a4792c4