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Health and carcinogenic risk evaluation for cohorts exposed to PAHs in petrochemical workplaces in Rawalpindi city (Pakistan)
- Publication Year :
- 2015
- Publisher :
- Taylor & Francis, 2015.
-
Abstract
- This study presents the analyses of urinary biomarkers (1-OHPyr, α- and β-naphthols) of polycyclic aromatic hydrocarbons (PAHs) exposure and biomarkers of effect (i.e. blood parameters) in petroleum-refinery workers (RFs) and auto-repair workers (MCs). Exposed subjects had higher concentrations of white blood cell (WBC) count than control subjects (CN) subjects (5.31 × 103 μL−1 in exposed vs. 5.15 × 103 μL−1 in CN subjects), while the biomarker of oxidative DNA damage (8-OHdG) was significantly higher in MCs. The exposure among these two cohorts could be influenced by the ambience of the workplaces; in fact, MCs’ shops are relatively damp and enclosed workplaces in comparison with the indoor environment of refineries. PAHs in the dust samples from mechanical workshops probably originated from mixed sources (traffic exhaust and petroleum spills), while the incremental lifetime cancer risk (ILCR) for MCs showed moderate-to-low cancer risk from exposure to dust-bound PAHs. The study shows that increasing PAH exposure can be traced in MC workstations and needs to be investigated for the safety of public health.
- Subjects :
- Adult
010504 meteorology & atmospheric sciences
Adolescent
Health, Toxicology and Mutagenesis
Oil and Gas Industry
010501 environmental sciences
01 natural sciences
Risk Assessment
Cohort Studies
Young Adult
Environmental health
Neoplasms
Occupational Exposure
Medicine
Humans
Pakistan
Cities
Polycyclic Aromatic Hydrocarbons
Child
Carcinogen
0105 earth and related environmental sciences
Aged
Vehicle Emissions
Waste management
business.industry
Traffic pollution
Public Health, Environmental and Occupational Health
Dust
General Medicine
Middle Aged
Urinary biomarkers
Pollution
Risk evaluation
Child, Preschool
Carcinogens
Occupational exposure
business
Risk assessment
Blood parameters
Biomarkers
Environmental Monitoring
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....10acdf1d708393b07d55022de736226e
- Full Text :
- https://doi.org/10.6084/m9.figshare.1326667.v1