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Expression variations of chromogranin A and α1,2,4 GABA(A)Rs in discrete limbic and brainstem areas rescue cardiovascular alterations
- Source :
- Neuroscience research. 77(1-2)
- Publication Year :
- 2013
-
Abstract
- Recent interferences of hemodynamic functions via modified brain neuronal mechanisms have proven to be major causes of dementia and sleeping disorders. In this work, cerebral expression differences of the neuroactive vesicular chromogranin A (CgA) and distinct α GABAAR subunits were detected in the facultative hibernating hamster. In particular, damaged neuronal fields of hypotensive torpor (TORP) state were correlated to elevated CgA and GABAAR α1, α4 mRNA levels in the paraventricular hypothalamic nucleus (PVN), central amygdalar nucleus (CeA) plus solitary tractus nucleus (NTS). Conversely, few neurodegeneration signals of hypertensive arousal (AROU) state, accounted for mostly lower CgA levels in the same areas. This state also provided increased α2-containing sites in amygdala, hippocampal and NTS neurons together with elevated α4-containing receptors in the periventricular hypothalamic nucleus (Pe). Interestingly in our hibernating model, CgA appeared to preferentially feature inhibitory neurosignals as indicated by preliminary perfusion of amygdalar sites with its highly specific antihypertensive derived peptide (catestatin) promoting GABA-dependent sIPSCs. Overall, evident neuronal damages plus altered expression capacities of CgA and α1-, α2-, α4-GABAARs in CeA, Pe, PVN as well as NTS during both hibernating states corroborate for the first time key molecular switching events guaranteeing useful cardiovascular rescuing abilities of neurodegenerative disorders.
- Subjects :
- endocrine system
medicine.medical_specialty
Hippocampal formation
Inhibitory postsynaptic potential
Amygdala
Cardiovascular System
Internal medicine
Cricetinae
Hibernation
medicine
Limbic System
Animals
Receptor
Neurons
biology
Mesocricetus
General Neuroscience
Neurodegeneration
Chromogranin A
General Medicine
medicine.disease
Receptors, GABA-A
medicine.anatomical_structure
Endocrinology
nervous system
biology.protein
Brainstem
Nucleus
Neuroscience
Brain Stem
Subjects
Details
- ISSN :
- 18728111
- Volume :
- 77
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Neuroscience research
- Accession number :
- edsair.doi.dedup.....10b3b0e795e02529935a4961e715cfed