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Effects of Pneumococcal Conjugate Vaccine on Genotypic Penicillin Resistance and Serotype Changes, Japan, 2010–2017
- Source :
- Emerging Infectious Diseases, Vol 24, Iss 11, Pp 2010-2020 (2018), Emerging Infectious Diseases
- Publication Year :
- 2018
- Publisher :
- Centers for Disease Control and Prevention, 2018.
-
Abstract
- To clarify year-to-year changes in capsular serotypes, resistance genotypes, and multilocus sequence types of Streptococcus pneumoniae, we compared isolates collected from patients with invasive pneumococcal disease before and after introductions of 7- and 13-valent pneumococcal conjugate vaccines (PCV7 and PVC13, respectively). From April 2010 through March 2017, we collected 2,856 isolates from children and adults throughout Japan. Proportions of PCV13 serotypes among children decreased from 89.0% in fiscal year 2010 to 12.1% in fiscal year 2016 and among adults from 74.1% to 36.2%. Although nonvaccine serotypes increased after introduction of PCV13, genotypic penicillin resistance decreased from 54.3% in 2010 to 11.2% in 2016 among children and from 32.4% to 15.5% among adults. However, genotypic penicillin resistance emerged in 9 nonvaccine serotypes, but not 15A and 35B. Multilocus sequence typing suggested that resistant strains among nonvaccine serotypes may have evolved from clonal complexes 156 and 81. A more broadly effective vaccine is needed.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Serotype
Genotype
Epidemiology
Penicillin Resistance
030106 microbiology
lcsh:Medicine
multilocus sequence typing
Microbial Sensitivity Tests
Penicillins
Biology
medicine.disease_cause
Effects of Pneumococcal Conjugate Vaccine on Genotypic Penicillin Resistance and Serotype Changes, Japan, 2010–2017
Serogroup
invasive pneumococcal disease
Pneumococcal conjugate vaccine
Pneumococcal Infections
lcsh:Infectious and parasitic diseases
Pneumococcal Vaccines
03 medical and health sciences
Antibiotic resistance
Japan
Streptococcus pneumoniae
medicine
Humans
lcsh:RC109-216
serotype
antimicrobial resistance
bacteria
Vaccines, Conjugate
Research
lcsh:R
Sequence types
Virology
Anti-Bacterial Agents
Bacterial Typing Techniques
pneumococcal conjugate vaccine
Infectious Diseases
Penicillin resistance
Multilocus sequence typing
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 10806059 and 10806040
- Volume :
- 24
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Emerging Infectious Diseases
- Accession number :
- edsair.doi.dedup.....10c7bd46c9264a93f58b63545247f9f6