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Role of hepatitis D virus in persistent alanine aminotransferase abnormality among chronic hepatitis B patients treated with nucleotide/nucleoside analogues
- Source :
- Journal of the Formosan Medical Association, Vol 120, Iss 1, Pp 303-310 (2021)
- Publication Year :
- 2020
-
Abstract
- Background: The biochemical response is a crucial indicator of prognosis in chronic hepatitis B (CHB) patients treated with nucleotide/nucleoside analogues (NAs). The impact of hepatitis D virus (HDV) infection on alanine aminotransferase normalization is elusive. Methods: The longitudinal study recruited 1185 CHB patients who received NAs. These patients were tested for anti-HDV antibody and HDV RNA at the initiation of anti-hepatitis B virus (HBV) therapy and annually for patients who were HDV-seropositive. ALT levels were examined at the first and second year of anti-HBV therapy. ALT abnormality was defined as ALT levels above 40 IU/mL in both male and female, and the risk factors associated with ALT abnormality were analysed. Results: Rates of seropositivity for anti-HDV and HDV RNA were 2.0% and 0.8% among 1185 NA-treated CHB patients, respectively. The strongest factor associated with ALT abnormality (>40 IU/mL) after first year treatment with NAs was HDV RNA seropositivity at year 1 (odds ratio [OR]/95% confidence interval [CI]: 31.44/3.49–283.56, P = 0.002), followed by liver cirrhosis (2.18/1.51–3.15, P
- Subjects :
- Male
medicine.medical_specialty
Hepatitis B virus
Cirrhosis
ALT normalization
Gastroenterology
Virus
03 medical and health sciences
0302 clinical medicine
Hepatitis B, Chronic
NAs
HDV
Internal medicine
Diabetes mellitus
HBV
medicine
Humans
Longitudinal Studies
lcsh:R5-920
biology
business.industry
Nucleotides
Alanine Transaminase
Nucleosides
General Medicine
Odds ratio
Hepatitis B
medicine.disease
Hepatitis D
030220 oncology & carcinogenesis
DNA, Viral
biology.protein
030211 gastroenterology & hepatology
Female
Hepatitis D virus
Antibody
Hepatitis Delta Virus
lcsh:Medicine (General)
business
Body mass index
Subjects
Details
- ISSN :
- 09296646
- Volume :
- 120
- Issue :
- 1 Pt 2
- Database :
- OpenAIRE
- Journal :
- Journal of the Formosan Medical Association = Taiwan yi zhi
- Accession number :
- edsair.doi.dedup.....10d200dff54b2d9e7d7bfa4250cffc23