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Parathyroid hormone and parathyroid hormone-related peptide, and their receptors
- Source :
- Encyclopedia Of Molecular Medicine
- Publication Year :
- 2004
-
Abstract
- Parathyroid hormone (PTH) has a central role in the regulation of serum calcium and phosphate, while parathyroid hormone-related peptide (PTHrP) has important developmental roles. Both peptides signal through the same receptor, the PTH/PTHrP receptor (a class B G-protein-coupled receptor). The different biological effects of these ligands result from their modes of regulation and secretion, endocrine vs. paracrine/autocrine. The importance of PTH and PTHrP is evident by the variety of clinical syndromes caused by deficiency or excess production of either peptide, and the demonstration that intermittent injection of PTH increases bone mass, and thus provides a means to treat osteoporosis. This, in turn, has triggered increased interest in understanding the mechanisms of PTH/PTHrP receptor action and the search for smaller peptide or non-peptide agonists that have efficacy at this receptor when administered non-parenterally.
- Subjects :
- medicine.medical_specialty
Growth-hormone-releasing hormone receptor
Biophysics
Parathyroid hormone
Biochemistry
Models, Biological
Bone and Bones
Structure-Activity Relationship
Thyrotropin-releasing hormone receptor
Internal medicine
medicine
Animals
Humans
Receptor
Autocrine signalling
Molecular Biology
Receptor, Parathyroid Hormone, Type 1
Chemistry
Parathyroid hormone receptor
Parathyroid Hormone-Related Protein
Cell Biology
Endocrinology
Models, Chemical
Hormone receptor
Parathyroid Hormone
Receptors, Parathyroid Hormone
Calcium-sensing receptor
hormones, hormone substitutes, and hormone antagonists
Signal Transduction
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 328
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Biochemical and biophysical research communications
- Accession number :
- edsair.doi.dedup.....10da64bc9a01ba47940ecc141588ab87