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Insights into the molecular features of the von Hippel–Lindau-like protein
- Publication Year :
- 2019
- Publisher :
- Springer, 2019.
-
Abstract
- We present an in silico characterization of the von Hippel-Lindau-like protein (VLP), the only known human paralog of the von Hippel-Lindau tumor suppressor protein (pVHL). Phylogenetic investigation showed VLP to be mostly conserved in upper mammals and specifically expressed in brain and testis. Structural analysis and molecular dynamics simulations show VLP to be very similar to pVHL three-dimensional organization and binding dynamics. In particular, conservation of elements at the protein interfaces suggests VLP to be a functional pVHL homolog potentially possessing multiple functions beyond HIF-1α-dependent binding activity. Our findings show that VLP may share at least seven interactors with pVHL, suggesting novel functional roles for this understudied human protein. These may occur at precise hypoxia levels where functional overlap with pVHL may permit a finer modulation of pVHL functions.
- Subjects :
- Male
Models, Molecular
0301 basic medicine
Protein Conformation
Bioinformatics
Placenta
In silico
Clinical Biochemistry
Molecular Dynamics Simulation
Biology
urologic and male genital diseases
Proteomics
Biochemistry
law.invention
03 medical and health sciences
Cancer
Hereditary neoplastic syndrome
Von Hippel–Lindau disease
Pregnancy
law
Testis
medicine
Animals
Humans
Protein Interaction Maps
Phylogeny
Sequence Homology, Amino Acid
030102 biochemistry & molecular biology
Organic Chemistry
Brain
Von hippel lindau
Hypoxia-Inducible Factor 1, alpha Subunit
medicine.disease
female genital diseases and pregnancy complications
Cell biology
030104 developmental biology
Hereditary Cancer Syndromes
Von Hippel-Lindau Tumor Suppressor Protein
Mutation
Suppressor
Female
Protein Binding
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....1111b40666473eee9350f3546d7fdd1c