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Fine-structural and immunohistochemical study of anterior pituitary cells of Snell dwarf mice
- Source :
- Cell and tissue research. 251(2)
- Publication Year :
- 1988
-
Abstract
- Snell dwarf mice display remarkable retardation of growth after birth and are known to lack prolactin (PRL), thyroid stimulating hormone (TSH) and growth hormone (GH). The aim of this study was to determine the reason for these hormonal deficiencies. We examined the fine structure of the gland and its immunohistochemical staining pattern with respect to antisera raised against PRL, TSH, GH, adrenocorticotrophic hormone (ACTH) and luteinizing hormone (LH). The gland of control mice reacted immunohistochemically against all antisera used, whereas only ACTH-producing cells (ACTH cells) and LH-producing cells (LH cells) were distinguished in the dwarf mice. ACTH cells in dwarf mice varied in cell shape, although they were similar in size to those of controls. The distribution of secretory granules in the cytoplasm varied from cell to cell. LH cells in the dwarf mice showed immature features, having poorly developed rough endoplasmic reticulum and Golgi apparatus. The cells were about half the size of controls, and secretory granules were smaller. In dwarf mice, non-granulated cells were encountered in addition to granulated ACTH and LH cells. Some of them formed small clusters, characteristic cell junctions being found between the cells; they thus appeared to be follicular cells. The above results suggest that hormone deficiency in Snell dwarf mice is a result of a defect in the hormone-producing cells in the gland.
- Subjects :
- endocrine system
medicine.medical_specialty
Histology
endocrine system diseases
Thyrotropin
Biology
Gonadotropic cell
Pathology and Forensic Medicine
Mice
Thyroid-stimulating hormone
Anterior pituitary
Pituitary Gland, Anterior
Pituitary Hormones, Anterior
Internal medicine
Follicular phase
medicine
Animals
Cell Biology
Immunohistochemistry
Prolactin
Mice, Mutant Strains
Microscopy, Electron
medicine.anatomical_structure
Endocrinology
Corticotropic cell
Luteinizing hormone
hormones, hormone substitutes, and hormone antagonists
Endocrine gland
Subjects
Details
- ISSN :
- 0302766X
- Volume :
- 251
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cell and tissue research
- Accession number :
- edsair.doi.dedup.....111810ddd47a4ccaaebc37bdc0c5b88a