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System-wide Analysis of the T Cell Response
- Source :
- Cell Reports, Vol 14, Iss 11, Pp 2733-2744 (2016)
- Publication Year :
- 2015
-
Abstract
- SummaryThe T cell receptor (TCR) controls the cellular adaptive immune response to antigens, but our understanding of TCR repertoire diversity and response to challenge is still incomplete. For example, TCR clones shared by different individuals with minimal alteration to germline gene sequences (public clones) are detectable in all vertebrates, but their significance is unknown. Although small in size, the zebrafish TCR repertoire is controlled by processes similar to those operating in mammals. Thus, we studied the zebrafish TCR repertoire and its response to stimulation with self and foreign antigens. We found that cross-reactive public TCRs dominate the T cell response, endowing a limited TCR repertoire with the ability to cope with diverse antigenic challenges. These features of vertebrate public TCRs might provide a mechanism for the rapid generation of protective T cell immunity, allowing a short temporal window for the development of more specific private T cell responses.
- Subjects :
- 0301 basic medicine
Male
T cell
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes
chemical and pharmacologic phenomena
Biology
General Biochemistry, Genetics and Molecular Biology
Germline
Article
03 medical and health sciences
0302 clinical medicine
Antigen
Calmodulin
medicine
Animals
RNA, Messenger
Antigens
Receptor
lcsh:QH301-705.5
Gene
Zebrafish
Genetics
T-cell receptor
hemic and immune systems
Sequence Analysis, DNA
Zebrafish Proteins
Acquired immune system
biology.organism_classification
030104 developmental biology
medicine.anatomical_structure
lcsh:Biology (General)
030220 oncology & carcinogenesis
Subjects
Details
- ISSN :
- 22111247
- Volume :
- 14
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Cell reports
- Accession number :
- edsair.doi.dedup.....111f8d4ddc09b9472d65e35a5a274850