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Genetic polymorphism of catechol-O-methyltransferase modulates the association of green tea consumption and lung cancer
- Source :
- European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 28(4)
- Publication Year :
- 2018
-
Abstract
- Tea polyphenols are strong antioxidants, which can be rapidly O-methylated by catechol-O-methyltransferase (COMT). Thus, it is possible that the genetic polymorphism of COMT can modulate the association of green tea consumption and lung cancer. Here, we designed a case-control study to evaluate the combined effect of green tea consumption and COMT genotypes on the risk of lung cancer. A total of 237 lung cancer patients and 474 healthy controls were recruited. Questionnaires were administered to obtain demographic data, smoking status, green tea consumption, fruits and vegetables intake, exposure to cooking fumes, and family history of lung cancer. Genotypes for COMT were identified by PCR. Smoking, green tea consumption, exposure to cooking fumes, and family history of lung cancer were associated with the development of lung cancer. When green tea drinkers carrying COMT HL/LL genotypes were selected as the reference group, drinkers carrying the COMT HH genotype had a higher risk for the development of lung cancer (odds ratio: 1.97, 95% confidence interval: 0.99-3.91). Among the current and ever smokers, the elevated risk for lung cancer was more apparent in green tea drinkers carrying the COMT HH genotype compared with green tea drinkers carrying COMT HL/LL genotypes (odds ratio: 5.84, 95% confidence interval: 1.75-19.45). Green tea drinkers with greater activity of the COMT genotype, whereby polyphenols are effectively excluded, will gain fewer protective benefits against lung cancer development.
- Subjects :
- Oncology
Male
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Epidemiology
Taiwan
Catechol O-Methyltransferase
Diet Surveys
Antioxidants
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
mental disorders
Genotype
medicine
Tobacco Smoking
Humans
030212 general & internal medicine
Family history
Lung cancer
Medical History Taking
Catechol-O-methyl transferase
Tea
business.industry
fungi
Public Health, Environmental and Occupational Health
Case-control study
food and beverages
Polyphenols
Odds ratio
Middle Aged
Green tea
medicine.disease
Confidence interval
respiratory tract diseases
030220 oncology & carcinogenesis
Case-Control Studies
Female
business
Subjects
Details
- ISSN :
- 14735709
- Volume :
- 28
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
- Accession number :
- edsair.doi.dedup.....114b57c5576c38b456d5ac528c4b2a85