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Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophaƫ rhamnoides L.) berries
- Source :
- Food Chemistry. 221:997-1003
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Phytochemical profiles, antioxidant and antiproliferative activities of berry extracts were evaluated and compared in four subspecies of Sea buckthorn (Hippophae rhamnoides L.). Among the subspecies, Hippophae rhamnoides L. subsp. sinensis exhibited highest total phenolics content (38.7±1.3mgGA equiv./g DW) and corresponding total antioxidant activity. Whereas maximum cellular antioxidant and antiproliferative activities were determined in Hippophae rhamnoides L. subsp. yunnanensis. Total antioxidant activity was significantly associated to total phenolics, isorhamnetin-3-rutinoside and isorhamnetin-3-glucoside. The cellular antioxidant activity and antiproliferative activity of phytochemicals were fairly correlated to phenolic acids and flavonoid aglycones. Lower median effective dose (EC50) of individual compounds against human liver cancer HepG2 cells proliferation studies confirmed the better correlation between antiproliferative activity of Sea buckthorn extracts and flavonoid aglycones, including isorhamnetin, quercetin and kaempferol.
- Subjects :
- Antioxidant
medicine.medical_treatment
Phytochemicals
Flavonoid
Berry
Antioxidants
Analytical Chemistry
chemistry.chemical_compound
0404 agricultural biotechnology
Phenols
Hippophae
Botany
medicine
Chromatography, High Pressure Liquid
Isorhamnetin
Flavonoids
chemistry.chemical_classification
Traditional medicine
biology
Plant Extracts
Hippophae rhamnoides
04 agricultural and veterinary sciences
General Medicine
biology.organism_classification
040401 food science
chemistry
Phytochemical
Fruit
Quercetin
Kaempferol
Food Science
Subjects
Details
- ISSN :
- 03088146
- Volume :
- 221
- Database :
- OpenAIRE
- Journal :
- Food Chemistry
- Accession number :
- edsair.doi.dedup.....1178a424a2dd47b80cad35395421bab6