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Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals
- Source :
- Scientific Reports, 9:9439. Nature Publishing Group, Scientific Reports, Scientific reports, vol. 9, no. 1, pp. 9439, Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019), Sci. Rep. 9:9439 (2019), Scientific Reports, 9(1):9439. Nature Publishing Group
- Publication Year :
- 2019
-
Abstract
- Type 2 diabetes (T2D) affects the health of millions of people worldwide. The identification of genetic determinants associated with changes in glycemia over time might illuminate biological features that precede the development of T2D. Here we conducted a genome-wide association study of longitudinal fasting glucose changes in up to 13,807 non-diabetic individuals of European descent from nine cohorts. Fasting glucose change over time was defined as the slope of the line defined by multiple fasting glucose measurements obtained over up to 14 years of observation. We tested for associations of genetic variants with inverse-normal transformed fasting glucose change over time adjusting for age at baseline, sex, and principal components of genetic variation. We found no genome-wide significant association (P −8) with fasting glucose change over time. Seven loci previously associated with T2D, fasting glucose or HbA1c were nominally (P
- Subjects :
- 0301 basic medicine
Blood Glucose
Male
PREDICTION
LOCI
lcsh:Medicine
Physiology
Genome-wide association study
Type 2 diabetes
VARIANTS
0302 clinical medicine
Weight loss
LS2_1
Medicine
Longitudinal Studies
lcsh:Science
POPULATION
RISK
education.field_of_study
Multidisciplinary
Medical genetics
Middle Aged
3. Good health
Phenotype
LIFE-STYLE INTERVENTION
Female
medicine.symptom
Non diabetic
Medical genetics, Type 2 diabetes
Genotype
515 Psychology
Population
WEIGHT-LOSS
Polymorphism, Single Nucleotide
White People
Article
NO
GENETIC ARCHITECTURE
Fasting glucose
03 medical and health sciences
TYPE-2
SDG 3 - Good Health and Well-being
Genetic variation
Humans
education
business.industry
lcsh:R
Genetic Variation
medicine.disease
PREVENTION
Genetic architecture
030104 developmental biology
Diabetes Mellitus, Type 2
lcsh:Q
3111 Biomedicine
sense organs
business
030217 neurology & neurosurgery
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....11947c65459d91659c9faf35413b67c3