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Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in Rats
- Source :
- Toxics, Vol 8, Iss 54, p 54 (2020), Toxics, Toxics; Volume 8; Issue 3; Pages: 54
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- The compound 6:2 chlorinated polyfluorinated ether sulfonate (F-53B), a replacement for perfluorooctanesulfonate (PFOS) in the electroplating industry, has been widely detected in numerous environmental matrices, human sera, and organisms. Due to regulations that limit PFOS use, F-53B use is expected to increase. Therefore, in this study, we performed a subchronic oral toxicity study of F-53B in Sprague Dawley (SD) rats. F-53B was administered orally once daily to male and female rats for 28 days at doses of 5, 20, and 100 mg/kg/day. There were no toxicologically significant changes in F-53B-treated rats, except in the thyroid gland. However, F-53B slightly reduced the serum concentrations of thyroid hormones, including triiodothyronine and thyroxine, compared with their concentrations in the vehicle group. F-53B also induced follicular hyperplasia and was associated with increased thyroid hormone biosynthesis-associated protein expression. These results demonstrate that F-53B is a strong regulator of thyroid hormones in SD rats as it disrupts thyroid function. Thus, caution should be exercised in the industrial application of F-53B as an alternative for PFOS.
- Subjects :
- medicine.medical_specialty
thyroid dysfunction
Health, Toxicology and Mutagenesis
Ether
010501 environmental sciences
subchronic oral toxicity
Toxicology
lcsh:Chemical technology
01 natural sciences
Article
03 medical and health sciences
chemistry.chemical_compound
Thyroid dysfunction
Internal medicine
medicine
lcsh:TP1-1185
music
030304 developmental biology
0105 earth and related environmental sciences
0303 health sciences
Chemical Health and Safety
music.instrument
Triiodothyronine
Chemistry
Thyroid
F-53B
Follicular hyperplasia
thyroid hormone
Sulfonate
medicine.anatomical_structure
Endocrinology
Once daily
Thyroid function
Subjects
Details
- Language :
- English
- ISSN :
- 23056304
- Volume :
- 8
- Issue :
- 54
- Database :
- OpenAIRE
- Journal :
- Toxics
- Accession number :
- edsair.doi.dedup.....11a411bcd326fb00ae6fd8d7d0fd5e09