Back to Search Start Over

Splenic infarction after Epstein-Barr virus infection in a patient with hereditary spherocytosis

Authors :
Miyuki Hayama
Keiichi Iwabuchi
Masaaki Higashihara
Miyuki Mukae
Tomiteru Togano
Yuhko Suzuki
Manabu Ohsaka
Ryouichi Horie
Masaaki Ichinoe
Koji Miyazaki
Hisaichi Fujii
Tsutomu Shichishima
Source :
International journal of hematology. 85(5)
Publication Year :
2007

Abstract

We describe the first patient with hereditary spherocytosis (HS) known to have developed splenic infarction following infectious mononucleosis (IM). An 18-year-old Japanese man was referred to our hospital in November 2004 because of continuous fever and icterus. He had undergone cholecystectomy at the age of 14 years. On patient admission in November 2004, a physical examination showed marked hepatosplenomegaly, icterus, and jaundice. He had a white blood cell count of 14.9 x 10(9)/L with 9.5% atypical lymphocytes, a red blood cell count of 2.93 x 10(12)/L, and a hemoglobin concentration of 7.8 g/dL. Microspherocytes were observed in the patient's peripheral blood smear, and immunoglobulin M antibody to Epstein-Barr virus (EBV) viral capsid antigen was detected. The patient's diagnosis was HS with IM. On day 4 of admission, the patient complained of severe abdominal pain. Abdominal computed tomography scanning revealed findings of splenic infarction. Two months after the occurrence of splenic infarction, a splenectomy was performed. A pathohistologic examination of the resected spleen revealed no evidence of thrombosis or arterial occlusion. We assume that the cause of splenic infarction was insufficient blood flow to oxygenate the entire spleen during the acute enlargement of the spleen.

Details

ISSN :
09255710
Volume :
85
Issue :
5
Database :
OpenAIRE
Journal :
International journal of hematology
Accession number :
edsair.doi.dedup.....11a671db58398ddc57e481c9725c8915