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Modulation of the Activity of Insulin-Dependent Enzymes of Lipogenesis by Glucocorticoids
- Source :
- European Journal of Biochemistry. 53:541-546
- Publication Year :
- 1975
- Publisher :
- Wiley, 1975.
-
Abstract
- Administration of triamcinolone or dexamethasone to rats led to a prompt, marked and persistent rise in liver acetyl-CoA carboxylase activity. The activity of fatty acid synthetase increased to a lesser extent and after a more prolonged glucocorticoid treatment, whereas the changes in that of NADP-malate dehydrogenase and ATP-citrate lyase were not appreciable. The overall channeling of [1-14-C]acetyl-CoA to fatty acids was enhanced. The triamcinolone effect on acetyl-CoA carboxylase activity appeared to be dependent on the coincident hyperinsulinemia since it was not obtained in alloxan-diabetic rats, whereas the alanine-aminotransferase-inducing effect of this hormone was additive to that of insulin deficiency. In adipose tissue triamcinolone treatment caused a reduction in the activity of all lipogenesis enzymes and blunted their response to insulin administration. The antagonism of glucocorticoids toward insulin, selectively modulating the responses of the insulin-sensitive enzymes in liver and adipose tissue is discussed. The rise in hepatic lipogenic capacity, through the retention of the ability of insulin to induce acetyl-CoA carboxylase, may be physiologically important in restraining the ketogenesis from acetyl-CoA despite the increased fat utilization during glucocorticoid excess.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Adipose tissue
Biology
Triamcinolone
Biochemistry
Dexamethasone
Diabetes Mellitus, Experimental
Ligases
Malate Dehydrogenase
Internal medicine
Ketogenesis
medicine
Hyperinsulinemia
Animals
Insulin
Acetyl-CoA carboxylase
Oxo-Acid-Lyases
Alanine Transaminase
medicine.disease
Rats
Pyruvate carboxylase
Kinetics
Endocrinology
Liver
Lipogenesis
ATP Citrate (pro-S)-Lyase
Fatty Acid Synthases
Glucocorticoid
Acetyl-CoA Carboxylase
medicine.drug
Subjects
Details
- ISSN :
- 14321033 and 00142956
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- European Journal of Biochemistry
- Accession number :
- edsair.doi.dedup.....11ed393ad235f05a2c71554a42aa34ca
- Full Text :
- https://doi.org/10.1111/j.1432-1033.1975.tb04097.x