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METastasis Reporting and Data System for Prostate Cancer as a Prognostic Imaging Marker in Castration-resistant Prostate Cancer
- Source :
- Clinical Genitourinary Cancer. 18:e391-e396
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background METastasis Reporting and Data System for Prostate Cancer (MET-RADS-P) has been proposed as a standard of data acquisition and interpretation for whole-body diffusion-weighted magnetic resonance imaging (WB-DWI) performed in men with advanced prostate cancer. The aim of this study is to demonstrate the clinical significance of the scores in castration-resistant prostate cancer (CRPC). Materials and Methods We retrospectively evaluated WB-DWI obtained from 72 patients with CRPC between 2014 and 2017, when disease progression was suspected at the time of starting a new line of anticancer therapy. Twenty-five (35%) and 30 (42%) patients had a treatment history that included taxane-based chemotherapy and new hormonal drugs, respectively. Results Active bone metastases were identified in 60 patients (83%; number of bone metastasis = 0, 1-2, 3-5, 6-10, and > 10: n = 12 [17%], 20 [28%], 11 [15%], 1 [1%], and 28 [39%], respectively). Progressive lymph node and visceral metastases were identified in 10 (14%) and 4 (6%), respectively. During the median follow-up period of 24 months, 36 (50%) died of prostate cancer. Cancer-specific survival (CSS) was significantly stratified according to the MET-RADS-P scores of osseous metastatic burden and the presence of visceral metastasis (P 10) and the presence of visceral metastasis were significant indicators of shorter CSS (P = .0036 and P = .0017, respectively). Conclusions The extent of bone metastasis and the presence of visceral metastasis on WB-DWI were associated with a shorter CSS in CRPC. MET-RADS-P score can be a prognostic imaging biomarker for CRPC.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Imaging biomarker
Urology
medicine.medical_treatment
030232 urology & nephrology
Bone Neoplasms
Metastasis
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Data Systems
Humans
Clinical significance
Lymph node
Aged
Retrospective Studies
Aged, 80 and over
Chemotherapy
Taxane
business.industry
Bone metastasis
Middle Aged
Prognosis
medicine.disease
Survival Rate
Prostatic Neoplasms, Castration-Resistant
Diffusion Magnetic Resonance Imaging
medicine.anatomical_structure
030220 oncology & carcinogenesis
Disease Progression
business
Follow-Up Studies
Information Systems
Subjects
Details
- ISSN :
- 15587673
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Clinical Genitourinary Cancer
- Accession number :
- edsair.doi.dedup.....11f3040a83419903a7a846572f426a18
- Full Text :
- https://doi.org/10.1016/j.clgc.2019.12.010