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Chronic, episodic nicotine exposure alters GABAergic synaptic transmission to hypoglossal motor neurons and genioglossus muscle function at a critical developmental age

Authors :
Lila Buls Wollman
Emily Gayle Flanigan
Ralph F. Fregosi
Source :
Journal of Neurophysiology. 128:1483-1500
Publication Year :
2022
Publisher :
American Physiological Society, 2022.

Abstract

Regulation of GABAergic signaling through nicotinic acetylcholine receptor (nAChR) activation is critical for neuronal development. Here, we test the hypothesis that chronic episodic developmental nicotine exposure (eDNE) disrupts GABAergic signaling, leading to dysfunction of hypoglossal motor neurons (XIIMNs), which innervate the tongue muscles. We studied control and eDNE pups at two developmentally vulnerable age ranges: postnatal days (P)1-5 and P10-12. The amplitude and frequency of spontaneous and miniature inhibitory postsynaptic currents (sIPSCs, mIPSCs) at baseline were not altered by eDNE at either age. In contrast, eDNE increased GABA

Details

ISSN :
15221598 and 00223077
Volume :
128
Database :
OpenAIRE
Journal :
Journal of Neurophysiology
Accession number :
edsair.doi.dedup.....11f54dfd47dd95b8d07e08105e90119f
Full Text :
https://doi.org/10.1152/jn.00397.2022