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The Underlying Regulated Mechanisms of Adipose Differentiation and Apoptosis of Breast Cells after Weaning
- Source :
- Current Protein & Peptide Science. 20:696-704
- Publication Year :
- 2019
- Publisher :
- Bentham Science Publishers Ltd., 2019.
-
Abstract
- Numerous experimental studies have demonstrated that a series of remodeling processes occurred in the adipose tissue during the weaning, such as differentiation. Fibroblasts in the breast at weaning stage could re-differentiate into mature adipocytes. Many transcriptional factors were involved in these processes, especially the PPARĪ³, C/EBP, and SREBP1. There is cell apoptosis participating in the breast tissue degeneration and secretory epithelial cells loss during weaning. In addition, hormones, especially the estrogen and pituitary hormone, play a vital role in the whole reproductive processes. In this review, we mainly focus on the underlying regulated mechanisms of differentiation of adipose tissue and apoptosis of breast cell to provide a specific insight into the physiological changes during weaning.
- Subjects :
- medicine.drug_class
Mammary gland
Cell
Adipose tissue
Apoptosis
Weaning
Biology
Biochemistry
03 medical and health sciences
0302 clinical medicine
Adipocytes
medicine
Animals
Humans
Breast
Molecular Biology
Transcription factor
030304 developmental biology
0303 health sciences
Cell Differentiation
Cell Biology
General Medicine
Cell biology
medicine.anatomical_structure
Estrogen
030220 oncology & carcinogenesis
Transcription Factors
Hormone
Subjects
Details
- ISSN :
- 13892037
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Current Protein & Peptide Science
- Accession number :
- edsair.doi.dedup.....11f58613a11c91df9d160fc3567a461b