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Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis
- Source :
- Annals of the Rheumatic Diseases, 72, 8, pp. 1375-81, Annals of the Rheumatic Diseases, 72, 1375-81, Annals of the rheumatic diseases, vol 72, iss 8, Annals of the rheumatic diseases, 72, 1375-1381. BMJ, Annals of the rheumatic diseases, 72(8), 1375-1381. BMJ Publishing Group, Annals of the Rheumatic Diseases, 72(8), 1375-1381. BMJ Publishing Group, Mirkov, M U, Cui, J, Vermeulen, S H, Stahl, E A, Toonen, E J M, Makkinje, R R, Lee, A T, Huizinga, T W J, Allaart, R, Barton, A, Mariette, X, Miceli, C R, Criswell, L A, Tak, P P, de Vries, N, Saevarsdottir, S, Padyukov, L, Bridges, S L, van Schaardenburg, D, Jansen, T L, Dutmer, E A J, van de Laar, M A F J, Barrera, P, Radstake, T R D J, van Riel, P L C M, Scheffer, H, Franke, B, Brunner, H G, Plenge, R M, Gregersen, P K, Guchelaar, H J & Coenen, M J H 2013, ' Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis ', Annals of the Rheumatic Diseases, vol. 72, no. 8, pp. 1375-1381 . https://doi.org/10.1136/annrheumdis-2012-202405, Annals of the Rheumatic Diseases, 72(8), 1375-1381
- Publication Year :
- 2012
- Publisher :
- BMJ, 2012.
-
Abstract
- Contains fulltext : 118482.pdf (Publisher’s version ) (Open Access) BACKGROUND: Treatment strategies blocking tumour necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA). However, a significant subset of patients does not respond for unknown reasons. Currently, there are no means of identifying these patients before treatment. This study was aimed at identifying genetic factors predicting anti-TNF treatment outcome in patients with RA using a genome-wide association approach. METHODS: We conducted a multistage, genome-wide association study with a primary analysis of 2 557 253 single-nucleotide polymorphisms (SNPs) in 882 patients with RA receiving anti-TNF therapy included through the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry and the database of Apotheekzorg. Linear regression analysis of changes in the Disease Activity Score in 28 joints after 14 weeks of treatment was performed using an additive model. Markers with p
- Subjects :
- Male
Oncology
DNA Mutational Analysis
Drug Resistance
IR-86362
Genome-wide association study
DCN PAC - Perception action and control
Cell morphology
Receptors, Tumor Necrosis Factor
Etanercept
Arthritis, Rheumatoid
Anti-TNF
Rheumatoid
Receptors
Monoclonal
2.1 Biological and endogenous factors
Immunology and Allergy
Registries
Aetiology
Humanized
Health aging / healthy living Pathogenesis and modulation of inflammation [IGMD 5]
Antibodies, Monoclonal
Single Nucleotide
Genomic disorders and inherited multi-system disorders [DCN PAC - Perception action and control IGMD 3]
Connective tissue disease
Antirheumatic Agents
Rheumatoid arthritis
Public Health and Health Services
Evaluation of complex medical interventions Auto-immunity, transplantation and immunotherapy [NCEBP 2]
Female
Genetic Markers
medicine.medical_specialty
Clinical Sciences
Immunology
METIS-291290
Rheumatoid Arthritis
Single-nucleotide polymorphism
Antibodies, Monoclonal, Humanized
Polymorphism, Single Nucleotide
Autoimmune Disease
Article
Antibodies
General Biochemistry, Genetics and Molecular Biology
Genomic disorders and inherited multi-system disorders DCN MP - Plasticity and memory [IGMD 3]
Molecular epidemiology [NCEBP 1]
Gene Polymorphism
Rheumatology
Internal medicine
Genetics
medicine
Humans
Polymorphism
Genomic disorders and inherited multi-system disorders Molecular epidemiology [IGMD 3]
Molecular epidemiology Aetiology, screening and detection [NCEBP 1]
Tumor Necrosis Factor-alpha
business.industry
Arthritis
Inflammatory and immune system
Human Genome
Adalimumab
medicine.disease
Infliximab
Arthritis & Rheumatology
Gene Expression Regulation
Pharmacogenetics
Genetic marker
Immunoglobulin G
Gene polymorphism
Tumor Necrosis Factor
Genetics and epigenetic pathways of disease Genomic disorders and inherited multi-system disorders [NCMLS 6]
business
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 14682060 and 00034967
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Annals of the Rheumatic Diseases
- Accession number :
- edsair.doi.dedup.....1200625a9d12ca0938a6cd05b0c87504