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An Environment-Wide Association Study (EWAS) on Type 2 Diabetes Mellitus
- Source :
- PLoS ONE, PloS one, vol 5, iss 5, PLoS ONE, Vol 5, Iss 5, p e10746 (2010)
- Publication Year :
- 2010
- Publisher :
- Public Library of Science (PLoS), 2010.
-
Abstract
- BackgroundType 2 Diabetes (T2D) and other chronic diseases are caused by a complex combination of many genetic and environmental factors. Few methods are available to comprehensively associate specific physical environmental factors with disease. We conducted a pilot Environmental-Wide Association Study (EWAS), in which epidemiological data are comprehensively and systematically interpreted in a manner analogous to a Genome Wide Association Study (GWAS).Methods and findingsWe performed multiple cross-sectional analyses associating 266 unique environmental factors with clinical status for T2D defined by fasting blood sugar (FBG) concentration > or =126 mg/dL. We utilized available Centers for Disease Control (CDC) National Health and Nutrition Examination Survey (NHANES) cohorts from years 1999 to 2006. Within cohort sample numbers ranged from 503 to 3,318. Logistic regression models were adjusted for age, sex, body mass index (BMI), ethnicity, and an estimate of socioeconomic status (SES). As in GWAS, multiple comparisons were controlled and significant findings were validated with other cohorts. We discovered significant associations for the pesticide-derivative heptachlor epoxide (adjusted OR in three combined cohorts of 1.7 for a 1 SD change in exposure amount; p
- Subjects :
- Aging
lcsh:Medicine
Genome-wide association study
Type 2 diabetes
Disease
010501 environmental sciences
01 natural sciences
Cohort Studies
Epidemiology
2.1 Biological and endogenous factors
Aetiology
lcsh:Science
2. Zero hunger
0303 health sciences
Multidisciplinary
Diabetes
Genetics and Genomics/Bioinformatics
Polychlorinated Biphenyls
3. Good health
Type 2
Research Article
Cohort study
medicine.medical_specialty
Exposome
Public Health and Epidemiology/Environmental Health
General Science & Technology
Population
Environment
03 medical and health sciences
Diabetes mellitus
Environmental health
Diabetes Mellitus
Genetics
medicine
Humans
Diabetes and Endocrinology/Type 2 Diabetes
Pesticides
Metabolic and endocrine
Nutrition
030304 developmental biology
0105 earth and related environmental sciences
gamma-Tocopherol
business.industry
Prevention
lcsh:R
Reproducibility of Results
Type 2 Diabetes Mellitus
medicine.disease
Carotenoids
Health Surveys
Biotechnology
Genetics, Population
Diabetes Mellitus, Type 2
lcsh:Q
business
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....1210acd2d8b7b32ab1c9c9a836d1d017