Back to Search
Start Over
Permanent diabetes mellitus in the first year of life
- Source :
- Scopus-Elsevier
- Publication Year :
- 2001
-
Abstract
- The pathogenesis of permanent diabetes mellitus diagnosed early in life is heterogeneous and, in most cases, not known. We aimed at identifying markers differentiating between non-autoimmune and autoimmune diabetes.The clinical, genetic and epidemiological features of 111 diabetic patients (62 males) who received insulin within 12 months of life were studied.The epidemic curve by age of diabetes onset revealed two subsets of patients at a cutoff of 180 days. In the group with diabetes onset before 180 days ("early onset" permanent diabetes) the analysis of HLA susceptibility heterodimers (available for 21 individuals) showed that 76% had a "protective" HLA genotype for Type I (insulin-dependent) diabetes mellitus as compared to 11.9% (5/42) of the later onset group. Accordingly, "early onset" children were less likely to have autoimmunity markers (4 out of 26 tested) than children with onset after 180 days (13 out 20 tested) (15.4% vs. 65.0%, p0.01). Of note, 19 out of 20 (or the 95%) patients who were born on the island of Sardinia, an Italian region where the incidence of Type I diabetes is six times higher than continental Italy (33/100,000/year vs 5/100,000/year), were included in the later onset group (180 days). Small-for-date birthweight, a possible sign of reduced foetal insulin secretion, was more common in the "early onset" group (OR=9.9, 95%-CI 2.6-38.6).These results, obtained in the largest population-based cohort of diabetic infants hitherto reported, suggest that "early onset" permanent diabetes cases differ from later onset cases and that most of them do not have an autoimmune pathogenesis.
- Subjects :
- Male
medicine.medical_specialty
non-autoimmune diabetes mellitus
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Birth weight
Population
Gestational Age
Permanent neonatal diabetes
Type I diabetes
HLA protective heterodimers
autoimmune enteropathy
Settore MED/13 - Endocrinologia
Cohort Studies
Islets of Langerhans
Risk Factors
Internal medicine
Diabetes mellitus
Internal Medicine
Medicine
Birth Weight
Humans
Insulin
Age of Onset
education
Autoantibodies
Autoimmune disease
education.field_of_study
business.industry
Infant, Newborn
Infant
Permanent neonatal diabetes mellitus
Infant, Low Birth Weight
medicine.disease
Diabetes Mellitus, Type 1
Italy
Cohort
Immunology
Female
Seasons
Age of onset
business
Subjects
Details
- ISSN :
- 0012186X
- Volume :
- 45
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Diabetologia
- Accession number :
- edsair.doi.dedup.....1224b9ccb1ebf63dbb696d1d759c8143