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Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice
- Source :
- Science Advances
- Publication Year :
- 2017
- Publisher :
- American Association for the Advancement of Science (AAAS), 2017.
-
Abstract
- Serotonin enhancement during developmental stages restores autism symptoms in a mouse model of human 15q11-13 duplication.<br />Serotonin is a critical modulator of cortical function, and its metabolism is defective in autism spectrum disorder (ASD) brain. How serotonin metabolism regulates cortical physiology and contributes to the pathological and behavioral symptoms of ASD remains unknown. We show that normal serotonin levels are essential for the maintenance of neocortical excitation/inhibition balance, correct sensory stimulus tuning, and social behavior. Conversely, low serotonin levels in 15q dup mice (a model for ASD with the human 15q11-13 duplication) result in impairment of the same phenotypes. Restoration of normal serotonin levels in 15q dup mice revealed the reversibility of a subset of ASD-related symptoms in the adult. These findings suggest that serotonin may have therapeutic potential for discrete ASD symptoms.
- Subjects :
- 0301 basic medicine
Serotonin
medicine.medical_specialty
DNA Copy Number Variations
genetic structures
Autism Spectrum Disorder
mouse model
CNV
Neurotransmission
Somatosensory system
Models, Biological
Synaptic Transmission
behavioral disciplines and activities
Chromosomes
Mice
03 medical and health sciences
0302 clinical medicine
15q duplication
mental disorders
medicine
Animals
Social Behavior
Psychiatry
Pathological
Research Articles
Multidisciplinary
behavior
business.industry
Pyramidal Cells
SciAdv r-articles
Brain
Somatosensory Cortex
medicine.disease
Phenotype
Disease Models, Animal
Glucose
030104 developmental biology
Autism spectrum disorder
dup
Autism
business
Neuroscience
030217 neurology & neurosurgery
Research Article
Subjects
Details
- ISSN :
- 23752548
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Science Advances
- Accession number :
- edsair.doi.dedup.....123292b37bbc00a1b0630ef6f5f9c505