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Molecular Biology of Atherosclerotic Ischemic Strokes
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 9372, p 9372 (2020), International Journal of Molecular Sciences
- Publication Year :
- 2020
- Publisher :
- NLM (Medline), 2020.
-
Abstract
- Among the causes of global death and disability, ischemic stroke (also known as cerebral ischemia) plays a pivotal role, by determining the highest number of worldwide mortality, behind cardiomyopathies, affecting 30 million people. The etiopathogenetic burden of a cerebrovascular accident could be brain ischemia (~80%) or intracranial hemorrhage (~20%). The most common site when ischemia occurs is the one is perfused by middle cerebral arteries. Worse prognosis and disablement consequent to brain damage occur in elderly patients or affected by neurological impairment, hypertension, dyslipidemia, and diabetes. Since, in the coming years, estimates predict an exponential increase of people who have diabetes, the disease mentioned above constitutes together with stroke a severe social and economic burden. In diabetic patients after an ischemic stroke, an exorbitant activation of inflammatory molecular pathways and ongoing inflammation is responsible for more severe brain injury and impairment, promoting the advancement of ischemic stroke and diabetes. Considering that the ominous prognosis of ischemic brain damage could by partially clarified by way of already known risk factors the auspice would be modifying poor outcome in the post-stroke phase detecting novel biomolecules associated with poor prognosis and targeting them for revolutionary therapeutic strategies.
- Subjects :
- 0301 basic medicine
Inflammasomes
Cerebral arteries
microglia
Disease
Review
neuroinflammation
Brain ischemia
lcsh:Chemistry
0302 clinical medicine
atherosclerosi
Stroke
lcsh:QH301-705.5
Spectroscopy
microRNA
General Medicine
MKEY
DKK-3
Computer Science Applications
microRNAs
Blood-Brain Barrier
Cardiology
medicine.symptom
Dectin-1
medicine.medical_specialty
Ischemia
Brain damage
Catalysis
Inorganic Chemistry
03 medical and health sciences
Internal medicine
Diabetes mellitus
medicine
ischemic stroke
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
business.industry
Organic Chemistry
AF
medicine.disease
Immunity, Innate
NLRP3 inflammasome
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
atherosclerosis
business
BBB
030217 neurology & neurosurgery
Dyslipidemia
CD200-CD200R
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences, Vol 21, Iss 9372, p 9372 (2020), International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....124fe5fbe15f08452230b3dc0fa115a4