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Prevalence of pulmonary hypertension in systemic sclerosis in European Caucasians and metaanalysis of 5 studies
- Source :
- The Journal of rheumatology. 37(11)
- Publication Year :
- 2010
-
Abstract
- Objective.To measure the prevalence of different types of pulmonary hypertension (PH) and to identify patients with systemic sclerosis (SSc) at highest risk in a multicenter European sample, with a metaanalysis of relevant studies.Methods.Consecutive patients with SSc recruited at 11 French and Italian centers underwent detailed evaluations, including Doppler echocardiography, chest computed tomography, pulmonary function tests, and right-heart catheterization (RHC), to detect the presence and causes of PH. A metaanalysis was performed, including data from 4 other studies.Results.Among 206 patients in whom it was suspected, PH was confirmed by RHC in 83 patients (7%). Precapillary PH was found in 64 patients (5%), of whom 42 had pulmonary arterial hypertension (PAH) and 22 had PH secondary to interstitial lung disease (ILD). RHC identified 17 patients (1%) with postcapillary PH secondary to left-heart disease. Patients with DLCO/alveolar volume < 70% were more likely to have precapillary PH (87.5% vs 42%; p < 0.0001). Precapillary and postcapillary PH were associated with advanced age (68 ± 14 vs 59 ± 12 yrs, p < 0.0001, and 74 ± 16 vs 61.5 ± 10 yrs, p < 0.0001, respectively). The metaanalysis of 3818 patients showed a prevalence of precapillary PH of 9% (95% CI 6%–12%) and identified advanced age, longer disease duration, and limited cutaneous disease subset as risk factors for this condition.Conclusion.The prevalence of precapillary PH in our multicenter study of SSc was 5%, and in the metaanalysis 9%. Our observations support use of RHC to confirm the presence of precapillary PH suspected by noninvasive testing. We also identified patients at high risk who should be carefully monitored.
- Subjects :
- Male
medicine.medical_specialty
Cardiac Catheterization
medicine.medical_treatment
Hypertension, Pulmonary
Immunology
Comorbidity
Doppler echocardiography
Gastroenterology
Severity of Illness Index
White People
Pulmonary function testing
Rheumatology
DLCO
Internal medicine
Severity of illness
medicine
Prevalence
Immunology and Allergy
Humans
Cardiac catheterization
Aged
Scleroderma, Systemic
medicine.diagnostic_test
business.industry
Respiratory disease
Interstitial lung disease
Age Factors
Middle Aged
medicine.disease
Pulmonary hypertension
Echocardiography, Doppler
Surgery
Logistic Models
Female
business
Subjects
Details
- ISSN :
- 0315162X
- Volume :
- 37
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- The Journal of rheumatology
- Accession number :
- edsair.doi.dedup.....1264cfdf646fc927168d556656cd9881