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A developmentally regulated switch from stem cells to dedifferentiation for limb muscle regeneration in newts
- Source :
- Nature Communications, Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
- Publication Year :
- 2015
-
Abstract
- The newt, a urodele amphibian, is able to repeatedly regenerate its limbs throughout its lifespan, whereas other amphibians deteriorate or lose their ability to regenerate limbs after metamorphosis. It remains to be determined whether such an exceptional ability of the newt is either attributed to a strategy, which controls regeneration in larvae, or on a novel one invented by the newt after metamorphosis. Here we report that the newt switches the cellular mechanism for limb regeneration from a stem/progenitor-based mechanism (larval mode) to a dedifferentiation-based one (adult mode) as it transits beyond metamorphosis. We demonstrate that larval newts use stem/progenitor cells such as satellite cells for new muscle in a regenerated limb, whereas metamorphosed newts recruit muscle fibre cells in the stump for the same purpose. We conclude that the newt has evolved novel strategies to secure its regenerative ability of the limbs after metamorphosis.<br />How limb regeneration in the newt is regulated at a cellular level is much debated. Here, the authors show different mechanisms acting at different developmental stages, namely stem/progenitor cells in larval regeneration and muscle fibres in the blastema regulate limb regeneration after metamorphosis.
- Subjects :
- 0301 basic medicine
Amphibian
Male
animal structures
media_common.quotation_subject
Science
Muscle Fibers, Skeletal
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
Article
03 medical and health sciences
biology.animal
Animals
Regeneration
Cell Lineage
Progenitor cell
Metamorphosis
media_common
Progenitor
Salamandridae
Larva
Multidisciplinary
biology
urogenital system
Regeneration (biology)
Muscles
Stem Cells
fungi
Metamorphosis, Biological
Extremities
General Chemistry
Anatomy
Cell Dedifferentiation
biology.organism_classification
Cell biology
body regions
Luminescent Proteins
030104 developmental biology
Cell Tracking
embryonic structures
Female
Stem cell
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Nature communications
- Accession number :
- edsair.doi.dedup.....1276c2ec2b01d96a109a226746b96370