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Ibopamine vs. digoxin in chronic heart failure: a double-blind, crossover study
- Source :
- Journal of cardiovascular pharmacology. 14
- Publication Year :
- 1989
-
Abstract
- Ibopamine, a dopamine derivative suitable for oral administration, is reported to improve cardiac function in patients with chronic heart failure. In order to evaluate the inotropic effect of ibopamine and to compare it with that of digoxin, we studied 10 patients with chronic heart failure (NYHA II-III). All patients were in sinus rhythm. After a washout period of 5 days, when the patients received a constant diuretic dosage and a placebo, ibopamine 100 mg t.i.d. or digoxin 0.25 mg o.d. was randomly given double-blind. The active treatment was continued for a 10-day period, and was followed by a second washout period of 5 days. Subsequently, the patients received digoxin if previously on ibopamine or ibopamine if previously on digoxin for 10 days. Diuretic was continued at the same dosage throughout the study. At the end of the two washout periods, all patients performed a static (hand grip) and a dynamic exercise (bicycle ergometer). Both ibopamine and digoxin improved cardiac response to both types of exercise compared to the washout periods. In particular, PEP/LVET decreased (p less than 0.001 for both drugs) and O2 consumption improved (from 586 +/- 48 to 716 +/- 35 ml/min for ibopamine and from 585 +/- 38 to 713 +/- 52 ml/min for digoxin). No difference was noted between the two drugs in the improvement of exercise tolerance. No side effects were noted with the two drugs. These data indicate that ibopamine could be a valid alternative to digoxin in heart failure patients in sinus rhythm when given for 10 days. More data are needed to evaluate the long-term efficacy of ibopamine.
- Subjects :
- Adult
Male
Digoxin
Cardiotonic Agents
medicine.medical_treatment
Dopamine
Vasodilator Agents
Digitalis
Placebo
Random Allocation
Oxygen Consumption
Double-Blind Method
Ibopamine
medicine
Humans
Sinus rhythm
Aged
Pharmacology
Heart Failure
biology
business.industry
Middle Aged
biology.organism_classification
medicine.disease
Crossover study
Deoxyepinephrine
Anesthesia
Heart failure
Chronic Disease
Exercise Test
Physical Endurance
Drug Evaluation
Female
Diuretic
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 01602446
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of cardiovascular pharmacology
- Accession number :
- edsair.doi.dedup.....127a6fc629488673d6a629b7b07d4025