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Real-world evidence on health resource use among patients with haemophilia and inhibitor exhibiting severe bleeding episodes
- Source :
- Haemophilia : the official journal of the World Federation of HemophiliaREFERENCES. 27(1)
- Publication Year :
- 2020
-
Abstract
- Objective This study aimed to explore real-world evidence on health resource use (HRU) spending on patients with haemophilia and inhibitor. Materials and methods Medical records from 1990 to 2019 of patients with haemophilia and inhibitor from three comprehensive haemophilia treatment centres were retrospectively retrieved. Results In all, 31 patients with haemophilia (A = 30, B = 1) and inhibitor ≥5 BU were included. The mean initial inhibitor of 95.4 BU was detected at the mean age of 6.7 years. The mean number of annual hospitalisations was 3.9. A total of 795 bleeding episodes (major =125, minor =670) were evaluated. The treatment included bypassing agents or plasma exchange before administering high-dose factor VIII concentrate and intervention or surgery. Six patients succumbed to bleeding at the mean age of 17.2 years. Nineteen surviving patients experienced multiple morbidity except six patients with successful and partially successful immune tolerance induction (ITI). The mean (SD) annual total medical consumption for episodic treatment and successful ITI per patient with haemophilia A were 30,804 (81,332) USD and 55,531 (100,566) USD, respectively. Only episodic treatment was paid by the government budget for limited amounts of bypassing agents. Conclusion Management for patients with haemophilia and inhibitor exhibiting severe bleeding is challenging for medical personnel in countries having limited resources over decades. The real-world data will be used to negotiate with the government to increase budget for adequate bypassing agents or nonreplacement therapy and to include ITI in the national haemophilia treatment.
- Subjects :
- Severe bleeding
Pediatrics
medicine.medical_specialty
Adolescent
Haemophilia A
Hemorrhage
030204 cardiovascular system & hematology
Real world evidence
Haemophilia
Hemophilia A
03 medical and health sciences
0302 clinical medicine
medicine
Immune Tolerance
Humans
Multiple morbidities
Child
Genetics (clinical)
Episodic treatment
Retrospective Studies
Factor VIII
business.industry
Medical record
Hematology
General Medicine
Health resource
medicine.disease
Recombinant Proteins
Health Resources
business
030215 immunology
Subjects
Details
- ISSN :
- 13652516
- Volume :
- 27
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Haemophilia : the official journal of the World Federation of HemophiliaREFERENCES
- Accession number :
- edsair.doi.dedup.....127eb37a7148ee3fb70ae35f71957451