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Clerodane diterpenoids from Scutellaria formosana with inhibitory effects on NO production and interactions with iNOS protein

Authors :
Yuanqiang Guo
Jing Xu
Peixia Wang
Shen Li
Da-Qing Jin
Yue Liang
Xueyuan Yang
Feng Liu
Guochen Su
Yasushi Ohizumi
Source :
Phytochemistry. 144:141-150
Publication Year :
2017
Publisher :
Elsevier BV, 2017.

Abstract

A phytochemical study on Scutellaria formosana afforded five previously undescribed spiro-diterpenoids, scutellapenes A−E. The structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analysis, and the absolute configurations of these compounds were established by the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. Scutellapenes B−E possess a spiro-diterpenoid skeleton. All of the compounds showed inhibitory effects on LPS-induced nitric oxide (NO) production in murine microglial BV-2 cells. The further molecular docking studies revealed that these bioactive compounds had strong interactions with the iNOS protein.

Details

ISSN :
00319422
Volume :
144
Database :
OpenAIRE
Journal :
Phytochemistry
Accession number :
edsair.doi.dedup.....12906c28d406683efe2d24c2506506f1
Full Text :
https://doi.org/10.1016/j.phytochem.2017.09.005