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Reduction of Ethyl Benzoylacetate and Selective Protection of 2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol: A New and Facile Synthesis of Tolterodine

Authors :
Dae-Jong Park
Jungnam Ko
Hakjune Rhee
Kathlia A. De Castro
Sungdae Park
Source :
Organic Process Research & Development. 11:918-921
Publication Year :
2007
Publisher :
American Chemical Society (ACS), 2007.

Abstract

A new and facile synthesis of tolterodine using ethyl benzoylacetate as the starting material was developed. Reduction using sodium borohydride in methanol followed by Friedel–Crafts alkylation uti...

Details

ISSN :
1520586X and 10836160
Volume :
11
Database :
OpenAIRE
Journal :
Organic Process Research & Development
Accession number :
edsair.doi.dedup.....1299e1dfddaa4a7d38db8db6dc76f196
Full Text :
https://doi.org/10.1021/op7001134