Back to Search
Start Over
Quantification of emerging micropollutants in an amphipod crustacean by nanoliquid chromatography coupled to mass spectrometry using multiple reaction monitoring cubed mode
Quantification of emerging micropollutants in an amphipod crustacean by nanoliquid chromatography coupled to mass spectrometry using multiple reaction monitoring cubed mode
- Source :
- Journal of Chromatography A, Journal of Chromatography A, Elsevier, 2016, 1456, pp.217-225. ⟨10.1016/j.chroma.2016.06.022⟩, Journal of Chromatography A, Elsevier, 2016, 1456 (1456), pp.217-225. ⟨10.1016/j.chroma.2016.06.022⟩
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- International audience; An innovative analytical method has been developed to quantify the bioaccumulation in an amphipod crustacean (Gammarus fossarum) of three micropollutants regarded as anthropic-pollution markers: carbamazepine, oxazepam, and testosterone. A liquid-liquid extraction assisted by salts, known as QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) was miniaturised and optimised, so it could be adapted to the low mass samples (approximatively 5 mg dry weight). For this same reason and in order to obtain good sensitivity, ultra-trace analyses were carried out by means of nanoliquid chromatography. A pre-concentration system by on-column trapping was optimised to increase the injection volume. In order to improve both sensitivity and selectivity, the multiple reaction monitoring cubed mode analyses (MRM3) were carried out, validated and compared to the classic MRM. To the best of our knowledge, this is the first time that MRM3 is coupled to nanoliquid chromatography for the analysis and detection of organic micropollutants
- Subjects :
- Male
ENVIRONMENTAL CONTAMINANTS
Nanoliquid chromatography
010501 environmental sciences
01 natural sciences
Biochemistry
ENDOCRINE DISRUPTORS
Analytical Chemistry
Tandem Mass Spectrometry
QUECHERS EXTRACTION
Nanotechnology
Testosterone
Solid phase extraction
Chromatography, High Pressure Liquid
biology
Oxazepam
Chemistry
LINEAR ION-TRAP
General Medicine
Bioaccumulation
SOLID-PHASE EXTRACTION
Carbamazepine
FRESH-WATER INVERTEBRATE
Environmental chemistry
RESIDUE ANALYSIS
Miniaturisation
QuEChERS
MRM3
Liquid-Liquid Extraction
Mass spectrometry
Quechers
[CHIM.ANAL]Chemical Sciences/Analytical chemistry
Animals
Amphipoda
0105 earth and related environmental sciences
Miniaturization
Chromatography
010401 analytical chemistry
Organic Chemistry
Extraction (chemistry)
Selected reaction monitoring
Reproducibility of Results
NANO-LIQUID CHROMATOGRAPHY
biology.organism_classification
0104 chemical sciences
Gammarus pulex
Gammarus fossarum
Injection volume
Amphipode crustacean
MULTICLASS PHARMACEUTICALS
GAMMARUS-PULEX
Water Pollutants, Chemical
Subjects
Details
- ISSN :
- 00219673 and 18733778
- Volume :
- 1456
- Database :
- OpenAIRE
- Journal :
- Journal of Chromatography A
- Accession number :
- edsair.doi.dedup.....12ad18fe27aca3242cfdfaf87681189e
- Full Text :
- https://doi.org/10.1016/j.chroma.2016.06.022