Food safety evaluation for the use of albendazole in fish: residual depletion profile and withdrawal period estimation

Made available in DSpace on 2020-12-12T01:56:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-02 Due to the lack of drugs regulated for aquaculture, we have evaluated the use of albendazole (ABZ)–a potential drug to be regulated for fish–under food safety perspectives assessing the depletion profile of ABZ and its main metabolites (albendazole sulphoxide–ABZSO, albendazole sulphone–ABZSO2 and albendazole amino sulphone–ABZ-2-NH2SO2) in fish fillets (muscle and skin) after single dose oral administration of 10 mg ABZ kg-1 body weight. For the drug administration, a suitable procedure for ABZ incorporation into fish feed was employed, obtaining good homogeneity of ABZ concentration among feed pellets (CV