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MOV10 sequesters the RNP of influenza A virus in the cytoplasm and is antagonized by viral NS1 protein
- Source :
- The Biochemical journal. 476(3)
- Publication Year :
- 2018
-
Abstract
- MOV10 has emerged as an important host antiviral factor. MOV10 not only inhibits various viruses, including human immunodeficiency virus type 1, hepatitis C virus and vesicular stomatitis virus, but also restricts the activity of retroelements long interspersed nucleotide element-1, Alu, SVA and intracisternal A particles. Here, we report that MOV10 suppresses influenza A virus infection through interacting with viral nucleoprotein (NP), sequestering viral RNP in the cytoplasm and causing the degradation of viral vRNA. The antiviral activity of MOV10 depends on the integrity of P-bodies. We also found that the antiviral activity of MOV10 is partially countered by viral NS1 protein that interferes with the interaction of MOV10 with viral NP and causes MOV10 degradation through the lysosomal pathway. Moreover, NS1-defective influenza A virus is more susceptible to MOV10 restriction. Our data not only expand the antiviral spectrum of MOV10 but also reveal the NS1 protein as the first viral antagonist of MOV10.
- Subjects :
- Cytoplasm
viruses
Hepatitis C virus
Biology
Viral Nonstructural Proteins
medicine.disease_cause
Biochemistry
03 medical and health sciences
P-bodies
Influenza A virus
medicine
Humans
Molecular Biology
030304 developmental biology
0303 health sciences
Host (biology)
030302 biochemistry & molecular biology
Cell Biology
biology.organism_classification
Virology
Nucleoprotein
HEK293 Cells
Ribonucleoproteins
Vesicular stomatitis virus
A549 Cells
Proteolysis
Intracisternal A-Particle
Lysosomes
RNA Helicases
Subjects
Details
- ISSN :
- 14708728
- Volume :
- 476
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Biochemical journal
- Accession number :
- edsair.doi.dedup.....12befbc7b900d92ba062b71ce57be8c6