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Treatment of secondary central nervous system involvement in systemic aggressive B cell lymphoma using R-MIADD chemotherapy: a single-center study
- Source :
- Chinese Neurosurgical Journal, Chinese Neurosurgical Journal, Vol 7, Iss 1, Pp 1-8 (2021)
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- Background Secondary central nervous system lymphoma (SCNSL) is defined as lymphoma involvement within the central nervous system (CNS) that originated elsewhere, or a CNS relapse of systemic lymphoma. Prognosis of SCNSL is poor and the most appropriate treatment is still undetermined. Methods We conducted a retrospective study to assess the feasibility of an R-MIADD (rituximab, high-dose methotrexate, ifosfamide, cytarabine, liposomal formulation of doxorubicin, and dexamethasone) regimen for SCNSL patients. Results Nineteen patients with newly diagnosed CNS lesions were selected, with a median age of 58 (range 20 to 72) years. Out of 19 patients, 11 (57.9%) achieved complete remission (CR) and 2 (10.5%) achieved partial remission (PR); the overall response rate was 68.4%. The median progression-free survival after CNS involvement was 28.0 months (95% confidence interval 11.0–44.9), and the median overall survival after CNS involvement was 34.5 months. Treatment-related death occurred in one patient (5.3%). Conclusions These single-centered data underscore the feasibility of an R-MIADD regimen as the induction therapy of SCNSL, further investigation is warranted.
- Subjects :
- Oncology
medicine.medical_specialty
medicine.medical_treatment
lcsh:Surgery
Single Center
lcsh:RC346-429
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Chemotherapy
B-cell lymphoma
lcsh:Neurology. Diseases of the nervous system
Ifosfamide
business.industry
Research
lcsh:RD1-811
medicine.disease
Lymphoma
B cell lymphoma
Regimen
SCNSL
Neurology
Central nervous system
030220 oncology & carcinogenesis
Cytarabine
Surgery
Rituximab
Neurology (clinical)
R-MIADD
business
030215 immunology
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20574967 and 20959370
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Chinese Neurosurgical Journal
- Accession number :
- edsair.doi.dedup.....12c0eb43a1c74e8a2602c3c1dcf5ef9f