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Direct voxel-based comparisons between grey matter shrinkage and glucose hypometabolism in chronic alcoholism
- Source :
- Journal of Cerebral Blood Flow and Metabolism, Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2016, 36 (9), pp.1625-1640. ⟨10.1177/0271678X15611136⟩, ResearcherID
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- Alcoholism is associated with widespread brain structural abnormalities affecting mainly the frontocerebellar and the Papez’s circuits. Brain glucose metabolism has received limited attention, and few studies used regions of interest approach and showed reduced global brain metabolism predominantly in the frontal and parietal lobes. Even though these studies have examined the relationship between grey matter shrinkage and hypometabolism, none has performed a direct voxel-by-voxel comparison between the degrees of structural and metabolic abnormalities. Seventeen alcoholic patients and 16 control subjects underwent both structural magnetic resonance imaging and 18F-2-fluoro-deoxy-glucose-positron emission tomography examinations. Structural abnormalities and hypometabolism were examined in alcoholic patients compared with control subjects using two-sample t-tests. Then, these two patterns of brain damage were directly compared with a paired t-test. Compared to controls, alcoholic patients had grey matter shrinkage and hypometabolism in the fronto-cerebellar circuit and several nodes of Papez’s circuit. The direct comparison revealed greater shrinkage than hypometabolism in the cerebellum, cingulate cortex, thalamus and hippocampus and parahippocampal gyrus. Conversely, hypometabolism was more severe than shrinkage in the dorsolateral, premotor and parietal cortices. The distinct profiles of abnormalities found within the Papez’s circuit, the fronto-cerebellar circuit and the parietal gyrus in chronic alcoholism suggest the involvement of different pathological mechanisms.
- Subjects :
- Adult
Cingulate cortex
Pathology
medicine.medical_specialty
Cerebellum
Thalamus
[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
[SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
Hippocampus
Brain damage
Grey matter
computer.software_genre
03 medical and health sciences
0302 clinical medicine
Voxel
Parietal Lobe
medicine
Humans
Gray Matter
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
[SCCO.NEUR]Cognitive science/Neuroscience
[SCCO.NEUR] Cognitive science/Neuroscience
Original Articles
Magnetic Resonance Imaging
030227 psychiatry
Alcoholism
Glucose
medicine.anatomical_structure
Neurology
nervous system
Case-Control Studies
Positron-Emission Tomography
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Chronic Disease
Neurology (clinical)
Atrophy
medicine.symptom
Cardiology and Cardiovascular Medicine
Psychology
Neuroscience
computer
030217 neurology & neurosurgery
Parahippocampal gyrus
Subjects
Details
- Language :
- English
- ISSN :
- 0271678X and 15597016
- Database :
- OpenAIRE
- Journal :
- Journal of Cerebral Blood Flow and Metabolism, Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2016, 36 (9), pp.1625-1640. ⟨10.1177/0271678X15611136⟩, ResearcherID
- Accession number :
- edsair.doi.dedup.....12cc806241c3de9b1b22f38b10f5eb6b