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Human Protease-Activated Receptor 1 Expression in Malignant Epithelia
- Source :
- Arteriosclerosis, Thrombosis, and Vascular Biology. 23:940-944
- Publication Year :
- 2003
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2003.
-
Abstract
- While protease-activated receptors (PARs) play a traditional role in vascular biology, they emerge with surprisingly new assignments in tumor biology. PAR1 expression correlates with the invasion properties of breast carcinoma, whereas human PAR1 antisense reduces their ability to migrate through Matrigel. Part of the molecular mechanism of PAR1 invasion involves the formation of focal contact complexes on PAR1 activation. PAR1 induces angiogenesis in animal models in vivo and exhibits an oncogenic phenotype of enhanced ductal complexity when overexpressed in mouse mammary glands.
- Subjects :
- Vascular Endothelial Growth Factor A
Integrins
Pathology
medicine.medical_specialty
Angiogenesis
Placenta
Breast Neoplasms
Biology
medicine.disease_cause
Mice
Pregnancy
In vivo
Morphogenesis
medicine
Animals
Humans
Neoplasm Invasiveness
Receptor, PAR-1
Receptors, Vitronectin
Breast
Neoplasm Metastasis
Receptor
Cytoskeleton
Mice, Knockout
Matrigel
Neovascularization, Pathologic
Thrombin
Epithelial Cells
Oligonucleotides, Antisense
Phenotype
Epithelium
Cell biology
Protease-Activated Receptor 1
medicine.anatomical_structure
cardiovascular system
Female
Cardiology and Cardiovascular Medicine
Carcinogenesis
Cell Division
Subjects
Details
- ISSN :
- 15244636 and 10795642
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Accession number :
- edsair.doi.dedup.....12cf7022225b9a52d939a3f60843766a