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Colon capsule versus computed tomography colonography for colorectal cancer screening in patients with positive fecal occult blood test who refuse colonoscopy: a randomized trial

Authors :
Frédéric Veniat
Julien Balique
Christine Chambon-Augoyard
M. G. Lapalus
Christell Ganne
Y Billaud
Luc Henry
Michel Bretagnolle
Romain Malezieux
Jean-Christophe Saurin
Léa Vecchiato
Antoine De Leusse
Jean-Charles Montoy
Olivia Scalone
Julien Marsot
Clémentine Gandilhon
Mathieu Pioche
Pierre-Jean Valette
Josiane Tomczyk-Ferrero
Antoine Detry
Patricia Soler-Michel
Emilie Del Tedesco
Annabel Taillandier
Benoit Russias
Thierry Ponchon
Alain Fond
Rodica Gincul
Jin Qiu
Source :
Endoscopy. 50(8)
Publication Year :
2018

Abstract

Objective Some patients (10 % – 32 %) with a positive guaiac fecal occult blood test (gFOBT) do not undergo the recommended colonoscopy. The aim of this study was to compare video capsule endoscopy (VCE) and computed tomography colonography (CTC) in terms of participation rate and detection outcomes when offered to patients with a positive gFOBT who did not undergo the recommended colonoscopy. Methods An invitation letter offering CTC or VCE was sent to selected patients after randomization. Acceptance of the proposed (or alternative) procedure and procedure results were recorded. Sample size was evaluated according to the hypothesis of a 13 % increase of participation with VCE. Results A total of 756 patients were targeted. Following the invitation letter, 5.0 % (19/378) of patients underwent the proposed VCE and 7.4 % (28/378) underwent CTC, ( P = 0.18). Following the letter, 9.8 % (37/378) of patients in the VCE group underwent a diagnostic procedure (19 VCE, 1 CTC, 17 colonoscopy) vs. 10.8 % in the CTC group (41/378: 28 CTC, 13 colonoscopy; P = 0.55). There were more potentially neoplastic lesions diagnosed in the VCE group than in the CTC group (12/20 [60.0 %] vs. 8/28 [28.6 %]; P = 0.04). Thus, 15/20 noninvasive procedures in the VCE group (19 VCE, 1 CTC; 75.0 %) vs. 10/28 in the CTC group (35.7 %; P = 0.01) resulted in a recommendation of further colonoscopy, but only 10/25 patients actually underwent this proposed colonoscopy. Conclusion Patients with a positive gFOBT result who do not undergo the recommended colonoscopy are difficult to recruit to the screening program and simply proposing an additional, less-invasive procedure, such as VCE or CTC, is not an effective strategy. ClinicalTrials.govNCT02558881TRIAL REGISTRATION: Randomized, controlled trial NCT02558881 at clinicaltrials.gov.

Details

ISSN :
14388812
Volume :
50
Issue :
8
Database :
OpenAIRE
Journal :
Endoscopy
Accession number :
edsair.doi.dedup.....12e124a1efa86aeedc9c66d90ca5aa7b