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The Central Nervous System as Target for Antihypertensive Actions of a Proline-Rich Peptide from Bothrops jararaca Venom
- Source :
- Repositório Institucional da UNIFESP, Universidade Federal de São Paulo (UNIFESP), instacron:UNIFESP, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2010
- Publisher :
- Wiley-Blackwell, 2010.
-
Abstract
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Pyroglutamyl proline-rich oligopeptides, present in the venom of the pit viper Bothrops jararaca (Bj-PROs), are the first described naturally occurring inhibitors of the angiotensin I-converting enzyme (ACE). the inhibition of ACE by the decapeptide Bj-PRO-10c (
- Subjects :
- Central Nervous System
Male
medicine.medical_specialty
Histology
chemistry.chemical_element
Biology
Calcium
calcium signaling
calcium imaging by confocal microscopy
fluorescence imaging plate reader analysis
Calcium in biology
Pathology and Forensic Medicine
pyroglutamyl proline-rich oligopeptides
neuronal cells
Calcium imaging
Internal medicine
Cell Line, Tumor
Renin–angiotensin system
Calcium flux
medicine
Animals
Homeostasis
Humans
Bothrops
Rats, Wistar
Antihypertensive Agents
Calcium signaling
Neurons
Neurotransmitter Agents
Microscopy, Confocal
Glutamate receptor
cardiovascular homeostasis
Cell Biology
snake peptide
HISTOLOGIA
Rats
Endocrinology
chemistry
Microscopy, Fluorescence
neurotransmitter release
G-protein coupled receptor
Proline-Rich Protein Domains
Oligopeptides
Intracellular
Snake Venoms
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Repositório Institucional da UNIFESP, Universidade Federal de São Paulo (UNIFESP), instacron:UNIFESP, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Accession number :
- edsair.doi.dedup.....12e4a605c2ea0354a8378a934c1400e0