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Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2

Authors :
Surya Pavan Yenamandra
Han Shi Jeri Lim
Carmen Koo
Hapuarachchige Chanditha Hapuarachchi
Lee Ching Ng
Zhen Yuan Yeo
Suzanna Chiang
School of Biological Sciences
Source :
Scientific Reports, Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Publication Year :
2021

Abstract

Dengue virus type 2 (DENV-2) contributes substantially to the dengue burden and dengue-related mortality in the tropics and sub-tropics. DENV-2 includes six genotypes, among which cosmopolitan genotype is the most widespread. The present study investigated the evolution, intra-genotype heterogeneity and dispersal of cosmopolitan genotype to understand unique genetic characteristics that have shaped the molecular epidemiology and distribution of cosmopolitan lineages. The spatial analysis demonstrated a wide geo-distribution of cosmopolitan genotype through an extensive inter-continental network, anchored in Southeast Asia and Indian sub-continent. Intra-genotype analyses using 3367 envelope gene sequences revealed six distinct lineages within the cosmopolitan genotype, namely the Indian sub-continent lineage and five other lineages. Indian sub-continent lineage was the most diverged among six lineages and has almost reached the nucleotide divergence threshold of 6% within E gene to qualify as a separate genotype. Genome wide amino acid signatures and selection pressure analyses further suggested differences in evolutionary characteristics between the Indian sub-continent lineage and other lineages. The present study narrates a comprehensive genomic analysis of cosmopolitan genotype and presents notable genetic characteristics that occurred during its evolution and global expansion. Whether those characteristics conferred a fitness advantage to cosmopolitan genotype in different geographies warrant further investigations.

Details

ISSN :
20452322
Volume :
11
Issue :
1
Database :
OpenAIRE
Journal :
Scientific reports
Accession number :
edsair.doi.dedup.....12e8ac03b650af345d512c3f12f150c1