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Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2
- Source :
- Scientific Reports, Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
- Publication Year :
- 2021
-
Abstract
- Dengue virus type 2 (DENV-2) contributes substantially to the dengue burden and dengue-related mortality in the tropics and sub-tropics. DENV-2 includes six genotypes, among which cosmopolitan genotype is the most widespread. The present study investigated the evolution, intra-genotype heterogeneity and dispersal of cosmopolitan genotype to understand unique genetic characteristics that have shaped the molecular epidemiology and distribution of cosmopolitan lineages. The spatial analysis demonstrated a wide geo-distribution of cosmopolitan genotype through an extensive inter-continental network, anchored in Southeast Asia and Indian sub-continent. Intra-genotype analyses using 3367 envelope gene sequences revealed six distinct lineages within the cosmopolitan genotype, namely the Indian sub-continent lineage and five other lineages. Indian sub-continent lineage was the most diverged among six lineages and has almost reached the nucleotide divergence threshold of 6% within E gene to qualify as a separate genotype. Genome wide amino acid signatures and selection pressure analyses further suggested differences in evolutionary characteristics between the Indian sub-continent lineage and other lineages. The present study narrates a comprehensive genomic analysis of cosmopolitan genotype and presents notable genetic characteristics that occurred during its evolution and global expansion. Whether those characteristics conferred a fitness advantage to cosmopolitan genotype in different geographies warrant further investigations.
- Subjects :
- 0301 basic medicine
Genotype
Science
Lineage (evolution)
030231 tropical medicine
Biology
Dengue virus
medicine.disease_cause
Genome
Molecular Evolution
Article
Dengue fever
Dengue
Evolution, Molecular
03 medical and health sciences
0302 clinical medicine
Viral Envelope Proteins
medicine
Humans
Gene
Phylogeny
Multidisciplinary
Molecular epidemiology
Biological sciences [Science]
Dengue Virus
medicine.disease
Phylogenetics
030104 developmental biology
Evolutionary biology
Medicine
Biological dispersal
Molecular evolution
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....12e8ac03b650af345d512c3f12f150c1