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Brain HIV-1 latently-infected reservoirs targeted by the suicide gene strategy
- Source :
- Virology Journal, Virology Journal, Vol 18, Iss 1, Pp 1-10 (2021)
- Publication Year :
- 2020
-
Abstract
- Several strategies are currently investigated to reduce the pool of all HIV-1 reservoirs in infected patients in order to achieve functional cure. The most prominent HIV-1 cell reservoirs in the brain are microglial cells. Virus infection maybe lifelong. Infected microglial cells are believed to be the source of peripheral tissues reseeding and responsible for the emergence of drug resistance. Clearing infected cells from the brain is therefore crucial. However, many characteristics of microglial cells and the central nervous system prevent the eradication of brain reservoirs. Current trials, such as “shock and kill”, the “deep and lock” and the gene editing strategies do not respond to these difficulties. Therefore, new strategies have to be designed when considering brain reservoirs such as microglial cells. We set up an original gene suicide strategy using a latently infected microglial model. In this paper we provide proof of concept of this strategy. Our results demonstrate that this strategy enables the eradication of latently-infected microglial cells.
- Subjects :
- 0301 basic medicine
CD4-Positive T-Lymphocytes
Central nervous system
Cell
Human immunodeficiency virus (HIV)
Short Report
HIV Infections
Drug resistance
Infectious and parasitic diseases
RC109-216
Biology
medicine.disease_cause
ASTROCYTES
ACTIVATION
MICROGLIA
03 medical and health sciences
0302 clinical medicine
Latent reservoirs
Genome editing
Virology
medicine
Humans
MACROPHAGES
Gene
Cells, Cultured
REACTIVATION
Gene Editing
Science & Technology
Microglia
Genes, Transgenic, Suicide
Brain
Suicide gene
BARRIER
Virus Latency
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
Microglial
CTIP2
Immunology
REPLICATION
HIV-1
Life Sciences & Biomedicine
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1743422X
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Virology journal
- Accession number :
- edsair.doi.dedup.....130cbdc40d4ffa5d0d71cd67d2282e0e