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Association of vascular brain injury, neurodegeneration, amyloid, and cognitive trajectory
- Source :
- Neurology
- Publication Year :
- 2020
-
Abstract
- ObjectiveTo determine whether vascular and neurodegenerative factors influence cognition before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and amyloid imaging in an ethnoracially diverse cohort of cognitively normal individuals older than 60 years.MethodsParticipants (n = 154; mean age 74.15 ± 6.94; 50% female; 54% Caucasian, 22.1% Hispanic, 14.9% African American) were recruited from the University of California, Davis Alzheimer's Disease Research Center, who were cognitively normal at baseline, time of PET, and MRI, and received yearly cognitive assessment for 6.23 ± 4.16 years. Mixed model regression with random slope and intercept was calculated for episodic memory and executive function, adjusting for age, sex, education, and ethnicity.ResultsVascular burden score was associated with total white matter hyperintensity (WMH) volume (β, 0.171; 95% confidence interval [CI], 0.024–0.318). WMH volume was associated with low baseline executive function (−0.115; −0.226 to −0.003) and rate of change in memory (−0.029; −0.045 to −0.012). Hippocampal volume was associated with the rate of change in memory (0.040; 0.021–0.059) and executive function (0.024; 0.008–0.039). Continuous measures of amyloid status influenced change in memory (−0.026; −0.044 to −0.008) and executive function (−0.033; −0.046 to −0.021) independently of MRI measures.ConclusionVascular brain injury and neurodegeneration are associated with baseline cognitive performance and the rate of longitudinal change independent of amyloid status among community-dwelling, ethnicity diverse cognitively normal individuals, supporting the role of vascular diseases as risk factors for later-life dementia.
- Subjects :
- Male
medicine.medical_specialty
Memory, Episodic
Plaque, Amyloid
Disease
Neuropsychological Tests
Hippocampus
050105 experimental psychology
Article
03 medical and health sciences
Executive Function
0302 clinical medicine
Cognition
Internal medicine
Medicine
Dementia
Humans
0501 psychology and cognitive sciences
Cognitive Dysfunction
Effects of sleep deprivation on cognitive performance
Episodic memory
Aged
Aged, 80 and over
Memory Disorders
Amyloid beta-Peptides
Aniline Compounds
medicine.diagnostic_test
business.industry
05 social sciences
Brain
Magnetic resonance imaging
Organ Size
medicine.disease
Magnetic Resonance Imaging
White Matter
Confidence interval
Cerebrovascular Disorders
Thiazoles
Positron-Emission Tomography
Cohort
Cardiology
Disease Progression
Female
Neurology (clinical)
Independent Living
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1526632X
- Volume :
- 95
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....131b2c1dda574ede0a6e1a5e3b44885b