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CIRCULATING SERUM LEVELS OF INTERLEUKIN 6 AND C-REACTIVE PROTEIN AFTER LIVER TRANSPLANTATION
- Source :
- Transplantation. 54:142-146
- Publication Year :
- 1992
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1992.
-
Abstract
- The study objectives were to investigate serum levels of interleukin-6 and C-reactive protein (CRP) after liver transplantation to correlated measurements with various clinical parameters. Twenty-three patients were studied after orthotopic liver transplantation. Serum IL-6 activity was evaluated by testing its capacity to induce proliferation of the IL-6-dependent hybridoma cell line B9. CRP was assessed by a nephelometric method. Only two of seven patients with acute cellular rejection developed an increase of serum IL-6 and CRP. In contrast to this rejection group, elevated IL-6 levels were observed in 7/9 patients with bacterial infections. Peak values for IL-6 were observed one day and for CRP two days after clinical diagnosis of infection. CMV disease was also associated with markedly increased IL-6 and CRP levels in 5/7 patients. Surprisingly, levels in this condition were approximately in the same range as in bacterial infection. IL-6 and CRP serum levels seen in bacterial infection and CMV disease were significantly higher than those in rejection (P less than 0.001). Serum IL-6 activity was neutralized by an antiserum directed against recombinant human IL-6. Preferential elevations of IL-6 and CRP represent one feature of bacterial and viral infections. Elevation of TNF during rejection as described earlier is only rarely accompanied by increased serum IL-6 levels.
- Subjects :
- Graft Rejection
Antiserum
Transplantation
biology
Interleukin-6
business.industry
medicine.medical_treatment
C-reactive protein
Interleukin
Bacterial Infections
Liver transplantation
Liver Transplantation
C-Reactive Protein
Cytokine
Cytomegalovirus Infections
Immunology
medicine
biology.protein
Humans
Tumor necrosis factor alpha
business
Interleukin 6
Subjects
Details
- ISSN :
- 00411337
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Transplantation
- Accession number :
- edsair.doi.dedup.....132141c92631271ff50640e2a1a4a1b5
- Full Text :
- https://doi.org/10.1097/00007890-199207000-00025